血浆分离器与血浆成分分离器对高脂血症性急性胰腺炎患者双重滤过血浆置换治疗研究  

Effect of plasma separator and plasma component separator EC series in achieving DFPP treatment for patients with HLAP

作　　者：白岩 郭瑞敏 陈静[3] 李向红 石勇 BAI Yan;GUO Rui-min;CHEN Jing(Department of Blood Transfusion,Jingdong Yumei Nephrotic Hospital of Integrated Traditional Chinese and Western Medicine,Sanhe 065201,China)

机构地区：[1]京东誉美中西医结合肾病医院输血科,河北三河065201 [2]河北省三河市医院检验科,河北三河065200 [3]河北医科大学第三医院输血科,河北石家庄050051 [4]京东誉美中西医结合肾病医院MICU,河北三河065201

出　　处：《中国医学装备》2021年第11期108-112,共5页China Medical Equipment

基　　金：河北省卫健委科研基金(20191304)“血液吸附治疗对高脂血症患者的疗效分析及治疗意义”。

摘　　要：目的:比较研究血浆分离器(OP-08W)组合血浆成分分离器(EC)系列用于高脂血症性急性胰腺炎(HLAP)患者双重滤过血浆置换(DFPP)治疗的效果。方法:选取在医院诊治的135例HLAP患者,按照DFPP治疗方法的不同,将给予OP-08W+EC-40 W治疗的患者纳入观察A组(43例),给予OP-08W+EC-50 W治疗的患者纳入观察B组(45例),将给予传统内科治疗的患者纳入对照组(47例)。比较3组患者禁食、入住重症监护室(ICU)时间、住院时间以及生长抑素或类似物使用时间,以及治疗前、治疗1周后血脂中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、急性生理学及慢性健康评估Ⅱ(APACHEⅡ)评分、C反应蛋白(CRP)、血清白蛋白(ALb)和纤维蛋白变化。结果:治疗后3组患者的禁食、入住ICU时间、住院时间以及生长抑素或类似物使用时间比较,差异有统计学意义(F=51.796,F=27.840,F=17.937,F=30.748;P<0.05),且观察A组、观察B组明显短于对照组,差异有统计学意义(t_(观察A组)=7.636,t=6.285,t=5.004,t=6.194;t_(观察B组)=7.871,t=6.139,t=4.848,t=6.215;P<0.05)。治疗1周后3组TC、TG和LDL-C均降低,HDL-C均升高,与治疗前比较差异有统计学意义(t(观察A组)=14.338,t=14.478,t=11.810,t=11.392;t_(观察B组)=16.996,t=22.022,t=20.205,t=11.626;t对照组=9.707,t=8.173,t=3.001,t=6.402;P<0.05),观察A组、观察B组明显低于对照组,差异有统计学意义(F=26.049,F=17.304,F=34.423,F=17.253;P<0.05)。治疗1周后3组APACHEⅡ评分、CRP均降低,且观察A组、观察B组明显低于对照组,差异有统计学意义(F=51.796,F=18.478;P<0.05)。结论:采用血浆分离器OP-08W和血浆成分分离器EC-40W、EC-50W进行DFPP治疗HLAP,均可有效清除血脂,降低炎症反应,缓解临床症状,缩短病程。Objective:To compare the effects of plasma separator OP-08W and plasma component separator EC series in dual filtration plasma plasmapheresis(DFPP)treatment for patients with hyperlipidemia acute pancreatitis(HLAP).Methods:135 HLAP patients who were diagnosed and treated in hospital were selected.According to the different DFPP treatment methods,the patients who were treated with OP-08W+EC-40 W were included in observation group A(43 cases),and those who were treated with OP-08W+EC-50 W were included in observation group B(45 cases),and the patients who received traditional medical treatment were included in control group(47 cases).The fasting,the time of admission to intensive care unit(ICU),length of stay,the time of using somatostatin or analogue,as well as total cholesterol(TC),triglycerides(TG),low-density lipoprotein-cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in blood lipids before and after treatment of 1 week,and acute physiology and chronic health evaluation II(APACHE II)score,C-reactive protein(CRP),serum albumin(ALb)and fibrous protein changes among three groups were compared.Results:After treatment,the differences of fasting,the time of the admission to ICU,length of stay,the time of using somatostatin or analog among three groups were compared,and the differences of those among three groups were statistically significant(F=51.796,F=27.840,F=17.937,F=30.748,P<0.05),and those of observation group A and observation group B were significantly shorter than those of control group(t_(observation group) A=7.636,t=6.285,t=5.004,t=6.194,t_(observation group) B=7.871,t=6.139,t=4.848,t=6.215,P<0.05),respectively.After 1 week of treatment,TC,TG and LDL-C of three groups were all decreased,while the HDL-C of them were increased,and the differences of them between before and after treatment were significant(t_(observation group) A=14.338,t=14.478,t=11.810,t=11.392,t_(observation group) B=16.996,t=22.022,t=20.205,t=11.626,t_(control group)=9.707,t=8.173,t=3.001,t=6.402,P<0.05).And those of obse

关 键 词：血浆分离器 血浆成分分离器 高脂血症性急性胰腺炎(HLAP) 双重滤过血浆置换(DFPP) 

分 类 号：R657.51[医药卫生—外科学]