血清Gal-3联合CAMI-STEMI评分对ST段抬高型心肌梗死患者PCI术后生存状况预测价值  

The value of serum Gal-3 combined with CAMI-STEMI score in predicting the survival status of patients with ST-segment elevation myocardial infarction after PCI

作　　者：李星阳 LI Xing-yang(The People’s Hospital of Chongzuo,Chongzuo 532200,China)

机构地区：[1]崇左市人民医院,广西崇左532200

出　　处：《中国处方药》2021年第11期136-138,共3页Journal of China Prescription Drug

摘　　要：目的探究血清半乳糖凝集素-3(Gal-3)联合中国心肌梗死注册登记研究-ST段抬高型心肌梗死(CAMI-STEMI)评分对ST段抬高型心肌梗死患者经皮冠状动脉介入治疗(PCI)术后生存状况预测价值。方法选取在2018年3月~2020年5月期间收治的ST段抬高型心肌梗死(STEMI)患者100例作为本次研究对象,按术后随访调查结果将其分为预后不良组(n=19)及预后良好组(n=81)。术前采集所有患者的外周静脉血,检测其血清Gal-3水平,对所有患者进行CAMI-STEMI评分。对比两组术前临床资料(CAMI-STEMI评分、发病至心肌再灌注时间、血管梗死位置、空腹血糖水平及血清Gal-3水平);比较术前血清Gal-3及CAMI-STEMI评分对STEMI患者PCI术后生存状况的预测价值;对STEMI患者PCI术后不良进行多因素COX回归分析。结果PCI术前,预后不良组CAMI-STEMI评分、发病至心肌再灌注时间及血清Gal-3水平均明显高于预后良好组(P<0.05),而空腹血糖水平两组差异无统计学意义(P>0.05)。预后良好组血管梗死位置近端49例(60.49%),预后不良组血管梗死位置近端11例(57.89%);两者联合的灵敏度为91.23%,高于单个指标,但其特异度有所降低为81.41%,而Youden指数高于其他两个单项指标,两者联合总体预测价值最高;进行COX回归分析,发现血管梗死位置近端、术前血清Gal-3水平及术前CAMI-STEMI评分均为STEMI患者PCI术后预后不良的独立因素(P<0.05)。结论术前血清Gal-3水平、CAMI-STEMI评分均为STEMI患者PCI术后生存状况的独立预测因素,且血清Gal-3联合CAMI-STEMI评分预测其生存状况有更高价值。Objective To explore the combination of serum galectin-3(Gal-3)and Chinese myocardial infarction registration study-ST-segment elevation myocardial infarction(CAMI-STEMI)score percutaneously in patients with ST-segment elevation myocardial infarction predictive value of survival status after coronary intervention(PCI).Methods A total of 100 patients with ST-segment elevation myocardial infarction(STEMI)admitted to our hospital from March 2018 to May 2020 were selected as the subjects of this study,and they were divided into poor prognosis groups according to the results of the postoperative follow-up survey(n=19)and good prognosis group(n=81).Before surgery,peripheral venous blood was collected from all patients to detect their serum Gal-3 levels,and all patients were scored with CAMI-STEMI.The preoperative clinical data(CAMI-STEMI score,time from onset to myocardial reperfusion,vascular infarction position,fasting blood glucose level and serum Gal-3 level)were compared between the two groups;the predictive value of post-surgical survival status of preoperative serum Gal-3 and CAMI-STEMI scores were compared for PCI in STEMI patients;Multivariate COX regression analysis was performed on the poor post-PCI of STEMI patients.Results Before PCI,the CAMI-STEMI score,time from onset to myocardial reperfusion,and serum Gal-3 levels in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05),while the fasting blood glucose levels were not significantly different between the two groups(P>0.05).49 cases(60.49%)of the proximal vascular infarction in the good prognosis group,11 cases(57.89%)in the proximal vascular infarction of the poor prognosis group;the sensitivity of the combination of the two was 91.23%,higher than the single index,but its specificity was reduced to 81.41%,and the Youden index was higher than the other two individual indicators,and the combination of the two had the highest overall predictive value;COX regression analysis showed that the proximal position of the

关 键 词：ST段抬高型心肌梗死 经皮冠状动脉介入治疗 CAMI-STEMI评分 半乳糖凝集素-3 预测价值 

分 类 号：R542.22[医药卫生—心血管疾病]