黄芪丹参合剂对气虚血瘀型冠心病经皮冠状动脉介入治疗术后肾脏保护的临床研究  

Clinical Study of Huangqi Danshen Mixture(黄芪丹参合剂)on Renal Protection of Coronary Heart Disease Patients with Qi Deficiency and Blood Stasis after PCI

作　　者：陈一坚[1] 江帆[1] 陈宇凯[1] CHEN Yijian;JIANG Fan;CHEN Yukai(Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,Zhejiang,China)

机构地区：[1]杭州师范大学附属医院,浙江杭州310015

出　　处：《中华中医药学刊》2021年第10期219-222,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划(2016ZA165)。

摘　　要：目的探讨黄芪丹参合剂对气虚血瘀型冠心病患者经皮冠状动脉介入治疗(PCI)术后肾脏功能的保护作用。方法将300例气虚血瘀型冠心病PCI术患者随机分为对照组和观察组,每组150例,对照组PCI围术期行常规水化疗法,观察组在对照组基础上加服黄芪丹参合剂。分别于术前及术后24、48 h行肾功能指标血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(eGFR)及血清胱抑素C(CysC)、β2微球蛋白(β2MG)、中性粒细胞明胶酶相关载脂蛋白(NGAL)的测定,并观察记录两组术后48h内造影剂肾病(CIN)及出院1个月不良事件发生情况。结果术后24 h,两组Scr、BUN、CysC、β2MG、NGAL相比术前均明显增高(P<0.05),eGFR相比术前均明显降低(P<0.05);术后48h,观察组上述血液指标均基本恢复至术前水平(P>0.05),而对照组与术前相比差异有统计学意义(P<0.05);在术后24 h、48 h的比较上,观察组Scr、BUN、CysC、β2MG、NGAL均明显低于对照组(P<0.05),eGFR均明显高于对照组(P<0.05)。观察组术后48 h内CIN发生率低于对照组(6.67%vs 20.67%),差异均有统计学意义(P<0.05);两组出院1个月不良事件发生率对比差异无统计学意义(P>0.05)。结论黄芪丹参合剂对气虚血瘀型冠心病患者PCI术后肾脏功能具有保护作用,能够有效预防CIN的发生。e Objective To investigate the protective effect of Huangqi Danshen Mixture(黄芪丹参合剂)on renal function after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD)with Qi deficiency and blood stasis.s Methods Three hundred patients with coronary heart disease with Qi deficiency and blood stasis undergoing PCI were randomly di-vided into control group and observation group,150 cases in each group.The control group received routine hydration therapy during perioperative period,while the observation group received Huangqi Danshen Mixture on the basis of the control group.Se-rum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(eGFR),serum cystatin C(CysC),β2 microglobulin(β2MG)and neutrophil gelatinase associated apolipoprotein(NGAL)were measured before operation and 24 and 48 hours after operation.The contrast medium nephropathy(CIN)within 48 hours after operation and the adverse events one month after dis-charge in the two groups were observed and recorded.s Results 24 hours after operation,Scr,BUN,CysC,β2MG and NGAL in both groups were significantly higher than those before operation(P<0.05).EGFR was significantly lower than that before oper-ation(P<0.05).48 hours after operation,the above blood indexes in the observation group basically returned to the preopera-tive levels(P>0.05),while those in the control group were significantly different from those before operation(P<0.05).24 h and 48 h after operation,the levels of Scr,BUN,CysC,β2MG and NGAL in the observation group were significantly lower than those in the control group,and eGFR in the observation group was significantly higher than that in the control group(P<0.05).The incidence of CIN within 48 hours after operation in the observation group was lower than that in the control group(6.67%vs20.67%),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse events one month after discharge between the two groups(P>0.05).n Conclusion Huangqi D

关 键 词：黄芪丹参合剂 冠心病 经皮冠状动脉介入治疗 造影剂肾病 肾功能 

分 类 号：R259.414[医药卫生—中西医结合]