Denting Nanospheres with a Short Peptide  

作　　者：Sha Lin Hui Sun Erik Jan Cornel Jin-Hui Jiang Yun-Qing Zhu Zhen Fan Jian-Zhong Du 

机构地区：[1]Department of Orthopedics,Shanghai Tenth People's Hospital,Tongji University,Shanghai 200072,China [2]Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China

出　　处：《Chinese Journal of Polymer Science》2021年第12期1538-1549,共12页高分子科学（英文版）

基　　金：by the National Science Fund for Distinguished Young Scholars,NSFC(No.21925505);Z.F.is supported by the National Natural Science Foundation of China(Nos.51803152,22075212);the program for professor of special appointment(Eastern Scholar)at Shanghai institutions of higher learning and Natural Science Foundation of Shanghai(19ZR1478800);Y.Z.is supported by the National Natural Science Foundation of China(No.51903190)and Shanghai Pujiang Program(No.19PJ140960);EJ.C.is supported by the China Postdoctoral Science Foundation(No.2020M671197).

摘　　要：Dented n anospheres show promisi ng potential in drug delivery,nano motors,etc.However,it is still challe nging to prepare them by homopolymer self-assembly because of the strict structural requirements of the homopolymer.Herein,we propose a strategy for preparing dented nano spheres from homopolymers by co-assembly with a short peptide.They were co-assembled from poly(2-hydroxy-3-((4-(ethoxycarbonyl)phenyl)amino)propyl methacrylate)(PHBzoMA59)and(S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpro-panamido)-3-phenyIpropanoic acid(Fmoc-FF-OH).PHBzoMA homopolymers can only self-assemble into nanospheres without dent,and the addition of a short peptide in troduced hydroge n bondi ng and complementary π-π stacki ng interactions led to the final dented nano sphere morphology.The weight fracti ons of the short peptide can be adjusted to regulate the final morphology.It was con firmed that the radius of curvature of the dent on the surface was related to the organic bubble inside the protospheres prepared at critical aggregation concentration(CAC).The orga nic bubble can be adjusted by altering the kind of orga nic solve nt and solution pH,which allowed control over the dented nano sphere dimension.The use of differe nt orga nic solve nts with various polarities allows adjustment of the interfacial tension,and hence the denting degree.This degree can also be controlled by manipulating the solution pH to(de)protonate the short peptide and homopolymer.Furthermore,the versatility of this method was highlighted by using a differe nt homopolymer and the applicability of the resulting den ted nanospheres was demonstrated by decoration with gold nanoparticles.Overall,this study provided important insights and a new simple strategy to prepare den ted n anospheres in a con trolled fashion.

关 键 词：Dented nanospheres HOMOPOLYMER Short peptide Hydrogen bonding π-πStacking 

分 类 号：O641.3[理学—物理化学] TB383.1[理学—化学]