Biocompatible,Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles  

作　　者：Cong-Lei Zhao Yu-Zhuang Gao Meng-Ying Wu Hang-Tian Zhang Yi-Xian Wu 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Beijing Advanced Innovation Center for Soft Matter Science and Engineering,Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Chinese Journal of Polymer Science》2021年第12期1550-1561,共12页高分子科学（英文版）

基　　金：by the National Natural Science Foundation of China(Nos.51521062 and 21574007).

摘　　要：The novel amphiphilic acylated dextran-g-polyisobutylene(AcyDex-g-PIB)graft copolymers with different branch lengths(A4nPtB,2600-5800 g/mol)and grafti ng numbers(GN,5-28 per 1000 Dex mono saccharide)were successfully synthesized via the nu cleophilic substitution of the hydroxyl(-OH)side groups along AcyDex backb one by the living PIB-THF4+chai ns prepared through cati onic polymerizatio n.The crystallizati on of AcyDex backb one in AcyDex-g-PIB graft copolymers was con fined due to the prese nee of PIB branches and the morphology changed from short rod-like crystals to fragment-like crystals with increasing Mn P|B and GN.The obvious microphase separation occurred due to the incompatibility between hard AcyDex backbone and soft PIB branches.AcyDex-g-PIB graft copolymers exhibit excellent biocompatibility towards HeLa cells and good hemocompatibility with red blood cells(RBCs),both of which increase with increasing GN.The in creases of water con tact angle and roughness on the surface of the graft copolymers with in creasi ng A4nP|B and GN manifest the anti-protein adsorption performance.The amphiphilic AcyDex-g-PIB graft copolymers could self-assemble in aqueous solution into nanospheres,which can be used as pH-sensitive drug carriers and can release 100%of the loaded drug within 72 h at pH=7.4.AcyDex-g-PIB graft copolymers bearing silver nanoparticles(Ag-NPs,0.8 wt%-3.9 wt%,4.5-9.5 nm)show good antibacterial properties.This kind of amphiphilic graft copolymer would have a promising prospect in biological and medical fields.

关 键 词：DEXTRAN POLYISOBUTYLENE Cationic polymerization Graft copolymer Biomedical application 

分 类 号：TQ317[化学工程—高聚物工业]