长非编码RNA基因MEG3在肿瘤发生、发展和诊断中的作用  

The Function of Long Noncoding RNA Gene MEG3 in Tumorigenesis,Development and Diagnosis

作　　者：刘晓倩 董艳秋 靳兰杰 李冬杰[2] 李世杰[1] LIU Xiao-Qian;DONG Yan-Qiu;JIN Lan-Jie;LI Dong-Jie;LI Shi-Jie(College of Life Science,Hebei Agricultural University,Baoding 071001,China;College of Bioscience and Bioengineering,Hebei University of Science and Technology,Shijiazhuang 050018,China)

机构地区：[1]河北农业大学生命科学学院,保定071000 [2]河北科技大学生物科学与工程学院,石家庄050018

出　　处：《农业生物技术学报》2021年第11期2223-2231,共9页Journal of Agricultural Biotechnology

基　　金：河北省自然科学基金(C2020204004);国家自然科学基金(C2020204004)。

摘　　要：长非编码RNA(lncRNA)作为一种重要的调节因子,参与调控细胞的各种正常生理过程,并在肿瘤的发生发展中发挥作用。母源等位基因表达的MEG3基因(maternally expressed gene 3),位于人(Homo sapiens)14号染色体q32.2的DLK1-DIO3印记区域内,34.9 kb的基因编码长度大约为1.6 kb的lncRNA。MEG3基因在多种癌变的组织和细胞中表达缺失或下调,表现出抑癌功能。MEG3通过调控肿瘤抑制基因和癌基因,如与p53、RB、MYC和TGF-β相互作用,从而调控肿瘤的发生。MEG3基因还通过调控Wnt-β-catenin信号通路,影响上皮-间质的转化。此外,位于MEG3基因位点的甲基化修饰和多态位点也与患癌的风险以及药物的治疗效果有关。本文针对MEG3基因在肿瘤发生中的作用机制,以及MEG3基因在作为癌症诊断和预后的生物标志物,以及作为治疗的靶标中的价值进行了论述。本文为后续研究MEG3在人类肿瘤治疗中的作用提供基础。Long non-coding RNAs(lncRNAs)are now considered as central regulators in normal biological activites and critically involved in the tumorigenesis.The maternally expressed gene 3(MEG3)is located in DLK1-DIO3 imprinted region on human chromosome 14 q32.2.MEG3 gene is composed of 34.9 kb size and encodes an approximately 1.6 kb lncRNA.The MEG3 is either lost or down-regulated in a many primary human tumors and tumors derived cell lines,and exhibits the function of tumor suppressor.MEG3 controls the expression of some tumor suppressor genes and oncogenes,such as p53,RB,MYC and TGF-β.MEG3 also affects epithelial-mesenchymal transition through regulating the Wnt-β-catenin signaling pathway.In addition,the methylation modification and polymorphic sites within the MEG3 locus are also associated with cancer risk of and drug therapeutic response of patients.In this review,several aspects of MEG3 participating in tumorigenesis,and the potential value in cancer diagnosis and prognosis are discussed.This article provides a basis for the follow-up study of the role of MEG3 in human tumor therapy.

关 键 词：MEG3(maternally expressed gene 3) 信号通路 P53 肿瘤 潜在的生物学标记 

分 类 号：S823[农业科学—畜牧学] S813.3[农业科学—畜牧兽医]