男性解脲脲原体感染对精液质量、精子功能及辅助生殖妊娠结局的影响  

The effects of male genital tract ureaplasma urealyticum positive on sperm quality,sperm function and the outcome of assisted reproductive technology

作　　者：梁鲁南[1] 孙宝刚[1] 曹井贺[1] 董业浩[1] 刘贞辉 Liang Lunan;Sun Baogang;Cao Jinghe;Dong Yehao;Liu Zhenhui(Affiliated Hospital of Jining Medical University,Jining,Shandong 272029)

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《中国男科学杂志》2021年第5期37-41,46,共6页Chinese Journal of Andrology

基　　金：山东省医药卫生科技发展项目(2015WS0410);济宁市科技发展项目[济科字(2015)57号-15]。

摘　　要：目的研究分析男性解脲脲原体感染患者的精液质量、精子功能、辅助生殖妊娠结局以及后代情况,探讨男性解脲脲原体感染对精液质量、精子功能、辅助生殖妊娠结局以及出生后代的影响。方法回顾分析济宁医学院附属医院生殖医学中心2016年1月至2019年12月因不孕原因为输卵管因素行辅助生殖助孕的130例男性解脲脲原体阳性,女性阴性患者作为实验组,男女解脲脲原体阴性患者为205例纳入对照组。对比以上两组精子质量、精子功能指标(诸如顶体酶、精子顶体完整性、精子核蛋白组型、精子-透明质酸结合率等)以及妊娠结局和出生后代指标。结果实验组与对照组一般资料的比较,男、女方患者的平均年龄、不孕年限、窦卵泡数,女方基础FSH,女方基础LH,HCG日E2水平,HCG日子宫内膜厚度比较,均无统计学意义(P>0.05)。实验组与对照组相比,精液参数中,精液量、精液浓度、前向运动率、精子活动率无统计学意义(P>0.05)。对照组正常形态率组高于实验组,有统计学意义。实验组顶体酶活性、精子-透明质酸结合率与对照组相比差异无统计学意义,实验组的DNA碎片、核蛋白组型与对照组相比,具有统计学意义;实验组的受精率,卵裂率、优质胚胎率,着床率、生化妊娠率、临床妊娠率与对照组相比无统计学意义。实验组的子代影响指标与对照组相比:实验组的早产率、出生体质量、双胎妊娠率、男婴比例、出生缺陷率与对照组相比无统计学意义。实验组的流产率高于对照组,但无统计学意义。结论男性解脲脲原体感染对男性精液质量、精子功能有一定的影响,而对辅助生殖妊娠结局及出生后代可能无明显不良影响。Objective To evaluate the effects of male genital tract ureaplasma urealyticum positive on spermatogenesis,sperm function,sperm quality and the outcome of Assisted reproductive technology.Methods A retrospective analysis was carried out in 130 infertile couples with genital tract ureaplasma urealyticum positive who undergo assisted reproductive technology treatments from January 2016 to December 2019.Other 205 men with normal and natural history of fertility was set as the control group.Sperm function and outcomes of assisted reproductive technology treatment were comparatively analyzed between the experience group and the control group.Results There were no significant differences between the experimental group and the control group in the average age and years of infertility,the number of the antral follicle,E_(2) level on HCG day,basic FSH,basic LH,intimal thickness on HCG day in male and female patients.There were no significant differences between the two groups in semen volume,sperm concentration,percentages of progressively motile sperm.but there was a significant difference in morphologically normal sperm.There were no significant differences in acrosin activity and sperm hyaluronic acid binding rate between the experimental group and the control group,The sperm DNA fragmentation and sperm nucleoprotein transition in the experimental group were higher than that in the control group,and the difference were statistically significant.The differences were no statistically significant in the clinical pregnancy rate of embryo rate,implantation rate and biochemical pregnancy rate between two groups.There was no significant difference in cleavage rate between the two groups in the ART treatment cycle group.There were no significant differences in the pregnancy rate of heavy twins,the proportion of male babies and the rate of birth defects between two groups.The abortion rate in the experimental group was higher than that in the control group,but the difference was not statistically significant.Conclusion Male gen

关 键 词：男性不育 支原体感染 脲原体属感染 辅助生殖技术 临床结局 

分 类 号：R518.9[医药卫生—内科学] R698.2[医药卫生—临床医学]