石墨烯材料在蛋白质和核酸分离/检测中的应用进展  

Application of Graphene in the Isolation/Detection of the Protein and Nucleic Acid

作　　者：陈蕾 李剑峰 邵立东 赵庆 黄章杰[2] Chen Lei;Li Jianfeng;Shao Lidong;Zhao Qing;Huang Zhangjie(School of Chinese Materia Medica,Yunnan University of Chinese Medicine,Kunming,650500;School of Chemical Science and Technology,Yunnan University,Kunming,650091)

机构地区：[1]云南中医药大学中药学院,昆明650500 [2]云南大学化学科学与工程学院,昆明650091

出　　处：《化学通报》2021年第11期1141-1149,共9页Chemistry

基　　金：云南省基础研究专项—青年项目(202001AU070134,202001AU070112);国家自然科学基金项目(51764051)资助。

摘　　要：石墨烯是碳材料家族新兴成员之一,因其具有化学性质稳定、良好生物兼容性、催化性、零带隙、特殊的电子能带等特点而受到科学家们广泛关注。石墨烯特殊的六元环基底平面对很多分子、离子具有亲和性,可通过非共价键或共价键将目标物质富集于表面,大多数情况下被吸附的物质在特定条件下易解吸且不会引起其结构和性质的改变。石墨烯因而在生物成像、生物医学、光催化、生物传感、药物载体和释放、环境等方面应用前景广阔。本文主要论述石墨烯和它的衍生物在生命大分子(蛋白质和核酸)分析化学方面的应用,并展望了其发展趋势。Graphene is one of the emerging members of the carbon material family.It has received extensive attention from scientists due to its stable chemical properties,good biocompatibility,catalytic properties,zero band gap,and special electronic energy bands.The special six-membered ring substrate plane of graphene has affinity for many molecules and ions.The target substance can be enriched on the surface through non-covalent bonds or covalent bonds.In most cases,the adsorbed substances are easy to be desorbed under specific conditions without causing changes in its structure and properties.Therefore,graphene has broad application prospects in bioimaging,biomedicine,photocatalysis,biosensing,drug carrier and release,environment,etc.This article mainly discusses the application progress of graphene and its derivatives in biomacromolecule(protein and nucleic acid)at bioanalytical chemistry,and looks forward to its application prospects.

关 键 词：蛋白质 核酸 石墨烯 生命分析化学 

分 类 号：TQ127.11[化学工程—无机化工] O629.7[理学—有机化学]