荧光探针在氰化物分析中的应用研究进展  

Progress in Fluorescent Probe for Cyanide Analysis

作　　者：徐芹芹 刘兆强 王华子 武海 Xu Qinqin;Liu Zhaoqiang;Wang Huazi;Wu Hai(School of Chemistry and Materials Engineering,Fuyang Normal University,Fuyang,236037;Anhui Province Key Laboratory of Environmental Hormone and Reproduction,Fuyang Normal University,Fuyang,236037)

机构地区：[1]阜阳师范大学化学与材料工程学院,阜阳236037 [2]阜阳师范大学环境激素与生殖发育安徽省重点实验室,阜阳236037

出　　处：《化学通报》2021年第11期1155-1162,共8页Chemistry

基　　金：安徽高校自然科学研究重大项目(KJ2019ZD37);阜阳市政府-阜阳师范学院横向合作项目(XDHX201701,XDHX201703,XHZ202010);阜阳师范大学科研创新团队(kytd202001)资助。

摘　　要：氰化物极易与细胞色素氧化酶键合,抑制电子转移、导致组织缺氧,从而显示较强的毒性。荧光化学传感器作为简易、灵敏且可视化的方法广泛应用于氰化物的检测。本文对荧光探针在氰化物检测中的应用进行介绍,概述了氰化物的毒性机制和荧光探针对氰化物的响应机理;同时,总结了荧光探针在水体、食品和生物组织中对氰化物的检测及生物成像中的应用,并对荧光探针在结构设计中如何提高生物兼容性和靶向性等进行了展望,以期为光化学探针分子的设计及应用提供理论与研究依据。Cyanide shows strong toxicity because it readily binds to the iron in cytochrome c oxidase,inhibiting electron transport and resulting in hypoxia.Fluorescent chemosensors are widely used in the detection of cyanide due to their simplicity,sensitivity,and visualization.In this paper,the applications of fluorescent probes in cyanide detection were reviewed and the toxicity mechanism of cyanide and the response mechanism of fluorescent probe to cyanide were summarized.Furthermore,we also summarized the applications of fluorescent probe for the detection and bioimaging of cyanide in water,food,and biological tissue.The prospect for improving the biological compatibility and targeting ability of the fluorescent probes in the structure design was also discussed,in order to provide theoretical and research basis for the design and application of photochemical probe molecules.

关 键 词：氰化物 荧光探针 荧光化学传感器 

分 类 号：O657.3[理学—分析化学] R996.2[理学—化学]