多种健脾消食中成药治疗儿童亚急性湿疹的对比研究  

Comparative study of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children

作　　者：杨明[1] 顾菲[1] 朱芸 刘晓雁[1] 高莹[1] YANG Ming;GU Fei;ZHU Yun;LIU Xiao-yan;GAO Ying(Department of Dermatology,Childrens Hospital Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院皮肤科,北京100020

出　　处：《中华全科医学》2021年第11期1875-1879,共5页Chinese Journal of General Practice

基　　金：国家自然科学基金项目(81703106)。

摘　　要：目的观察比较多种健脾消食中成药治疗儿童亚急性湿疹的临床疗效和安全性。方法回顾分析2018年6月—2019年6月首都儿科研究所附属儿童医院收治的186例儿童亚急性湿疹患儿的病例资料。按不同治疗方案将患儿分为对照组(48例,采用常规西药治疗)和观察组(138例,在常规西药治疗基础上联用健脾消食的中成药),观察组按给予中成药的不同分为A组(42例)、B组(57例)和C组(39例),分别给予的中成药为小儿扶脾颗粒、小儿康颗粒和神曲消食口服液。比较4组患儿的临床疗效、复发情况、瘙痒程度、生活质量及不良反应。结果 1个疗程治疗后,观察组A组、B组和C组的治疗总有效率(83.33%、85.96%、79.49%)均高于对照组的58.33%,且B组与对照组间的差异有统计学意义(P<0.008);1个疗程治疗后,观察组A组、B组和C组的瘙痒程度评分[(0.64±0.53)分、(0.49±0.37)分、(0.56±0.48)分]和生活质量评分[(5.24±1.93)分、(5.04±1.01)分、(5.59±2.13)分]均明显优于对照组[(1.41±0.72)分和(8.70±2.91)分,均P<0.05],但A、B、C 3组间两两比较差异无统计学意义(均P>0.05)。A、B、C 3组患儿3个月的湿疹复发率均明显低于对照组(均P<0.008),且B组3个月湿疹复发率(19.30%)明显低于A组(46.34%,P<0.008)。各组患者在治疗期间仅发生轻微不良反应,且不良反应发生率比较差异无统计学意义(P>0.05)。结论在健脾消食中成药和常规西药联合治疗儿童亚急性湿疹中,小儿康颗粒在提高疗效和降低复发率上更有优势,值得进一步关注。Objective To observe and compare the clinical efficacy and safety of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children.Methods The clinical data of 186 cases of children with subacute eczema treated in the Children’s Hospital Capital Institute of Pediatrics from June 2018 to June 2019 were retrospectively analyzed.The children were divided into control group(48 cases,conventional Western medicine)and observation group(138 cases,combined with Chinese patent medicines for strengthening spleen and digestion on the basis of the treatment of the control group)according to the treatment plan.The observation group was divided into group A(42 cases),group B(57 cases)and group C(39 cases)according to the difference of Chinese patent medicine,and the medicines included Xiaoerfupi Granule,Xiaoerkang Granule and Shenquxiaoshi Oral Liquid.Then,the efficacy,recurrence,pruritus,quality of life and adverse reactions were compared.Results After one course of treatment,the total effective rates of observation groups A,B and C(83.33%,85.96%and 79.49%,respectively)were higher than that of the control group(58.33%),and the difference between group B and the control group was significant(P<0.008).After one course of treatment,the pruritus and quality of life scores of observation groups A,B and C[the pruritus score was(0.64±0.53)points,(0.49±0.37)points and(0.56±0.48)points,respectively;CDLQI scores were(5.24±1.93)points,(5.04±1.01)points and(5.59±2.13)points,respectively]were significantly improved compared with the control group[pruritus score and CDLQI score were(1.41±0.72)points and(8.70±2.91)points,respectively,all P<0.05].However,no significant difference was observed amongst the three observation groups(all P>0.05).The recurrence rates of eczema at 3 months in the three observation groups were obviously lower than that in the control group(P<0.008),and this rate at 3 months was significantly lower in group B(19.30%)than in group A(46.34%,P<0.008).On

关 键 词：儿童湿疹 亚急性 健脾消食中成药 

分 类 号：R758.23[医药卫生—皮肤病学与性病学] R286[医药卫生—临床医学]