microRNA-145在子宫内膜异位症中的研究进展  

Research progress of microRNA-145 in endometriosis

作　　者：高爽 徐鹏[2] 王蓓蒂[1] 李栗扬 郭钰 匡野[1] GAO Shuang;XU Peng;WANG Bei-di;LI Li-yang;GUO Yu;KUANG Ye(Department of Obstetrics and Gynaecology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China;不详)

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第二医院院长办公室

出　　处：《中华全科医学》2021年第11期1921-1924,共4页Chinese Journal of General Practice

基　　金：吴阶平医学基金会临床科研课题项目(320675018061)。

摘　　要：子宫内膜异位症(EMs)是一种常见的雌激素依赖性疾病,病因尚不明确。表观遗传异常可能是EMs的潜在致病机制,它改变了激素和环境因素对基因表达的反应,其中小分子RNA(miRNA)的差异性表达在EMs的发生、发展过程中发挥一定作用。miRNA是一种非编码调节性单链RNA,通过与信使RNA(mRNA)的3'非编码区(3'UTR)结合在转录或转录后的水平上调节基因表达。已有大量的研究揭示了miRNA作为EMs潜在的强有力的生物标记,这些失调的miRNA中,有些直接参与了疾病的发生,而另一些则与疾病的存在相关,但它们的生物学作用尚不清楚。在这些miRNA中,miR-145在EMs中存在明显的差异性表达。miR-145通过介导细胞黏附分子和细胞骨架元素,如纤溶酶原激活物抑制物-1(PAI-1)、八聚体结合转录因子4(OCT4)以及肌成束蛋白-1(FSCN1)等因子影响内异症病灶的生成。miR-145还受其上游RNA分子的调控,如长链非编码RNA(lncRNA)前列腺癌相关转录物1(PCAT1)可通过miR-145信号通路靶向调控特定基因的表达,从而对EMs的患病风险产生影响。此外,miR-145表达水平的变化可能与EMs中的不孕症有关。本文旨在阐述miR-145在内异症中的作用机制,主要包括细胞的血管形成、腹膜黏附、侵袭、迁移、增殖、自噬、不孕症等内容,以期为临床治疗EMs提供进一步的理论支持。Endometriosis(EMs)is a common oestrogen-dependent disease,the cause of which is not clear.Epigenetic abnormality may be a potential pathogenic mechanism of EM,which changes the response of hormones and environmental factors to gene expression.Amongst them,small microRNAs(miRNAs)are differentially expressed in EM and play a certain role in the occurrence and development of the disease.miRNAs are non-coding regulatory single-stranded RNAs that regulate gene expression at the transcription or post-transcription level by binding to the 3′untranslated region of mRNA.Several studies have revealed that miRNAs are potentially powerful biomarkers of EM.Some of these dysregulated miRNAs are directly involved in the occurrence of diseases,whilst others are related to the existence of diseases.However,their biological role is unclear.Amongst these miRNAs,miR-145 has obvious differential expression in EM.miR-145 mediates cell adhesion molecules and cytoskeletal elements,such as plasminogen activator inhibitor-1,octamer-binding transcription factor-4 and FSCN1.miR-145 is also regulated by its upstream RNA molecules.For example,long non-coding RNA prostate cancer-associated transcript 1 can have an impact on the risk of EM through the miR-145 signalling pathway that targets and regulates the expression of specific genes.In addition,the changes of miR-145 expression levels may be related to infertility in EM.This study aims to describe the mechanism of action of miR-145 in EM,including cell angiogenesis,peritoneal adhesion,invasion,migration,proliferation,autophagy and infertility,in order to provide further theoretical support for the clinical treatment of EM.

关 键 词：microRNA-145 子宫内膜异位症 发病机制 

分 类 号：R711.71[医药卫生—妇产科学]