剑叶三宝木的化学成分研究  

Chemical constituents of Trigonostemon xyphophylloides

作　　者：王博闻 左遨勋 马国需[3] 李榕涛[2] 陈德力[2] 刘平怀[1] WANG Bo-wen;ZUO Ao-xun;MA Guo-xu;LI Rong-tao;CHEN De-li;LIU Ping-huai(School of Chemical Engineering and Technology,Hainan University,Haikou 570228,China;Hainan Key Laboratory of Resources Conservation and Development of Southern Medicine,Hainan Branch Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Haikou 570311,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]海南大学化学工程与技术学院,海南海口570228 [2]中国医学科学院北京协和医学院药用植物研究所海南分所,海南省南药资源保护与开发重点实验室,海南海口570311 [3]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中草药》2021年第20期6157-6162,共6页Chinese Traditional and Herbal Drugs

基　　金：海南省重点研发计划(ZDYF2020111)。

摘　　要：目的研究剑叶三宝木Trigonostemonxyphophylloides的化学成分。方法运用硅胶柱色谱、半制备高效液相色谱等方法进行分离纯化,结合现代波谱技术及理化常数鉴定结构。结果从剑叶三宝木中分离得到了12个化合物,包括8个二萜类、2个香豆素类、1个苯基丙烯衍生物、1个木脂素类,分别鉴定为补骨脂素(1)、异补骨脂素(2)、3,4,5-三甲氧基肉桂醛(3)、domohinone(4)、12-hydroxy-13-methylpodocarpa-9,11,13-trien-3-one(5)、sonderianol(6)、trigonostemone(7)、trigoxyphin N(8)、trigonochinene E(9)、trigoxyphin A(10)、trigoxyphin Q(11)、2,6,2′,6′-四甲氧基-4,4′-双(2,3-环氧-1-羟丙基)联苯(12)。结论化合物1~5为首次从该属植物中分离得到,化合物6、7、9、11、12为首次从该种植物中分离得到。Objective To study the chemical constituents from Trigonostemon xyphophylloides. Methods The constituents were isolated from the stems of T. xyphophylloides. and purified by column chromatography, and the structures were identified by spectral analysis and chemical methods. Results A total of 12 compounds were isolated from T. xyphophylloides, including eight diterpenoids, two coumarins, one phenyl propene derivatives and one lignan, and the structures were identified as psoralen(1),isopsoralen(2), 3,4,5-trimethoxy cinnamaldehyde(3), domohinone(4), 12-hydroxy-13-methylpodocarpa-9,11,13-trien-3-one(5),sonderianol(6), trigonostemone(7), trigoxyphin N(8), trigonochinene E(9), trigoxyphin A(10), trigoxyphin Q(11),2,6,2′,6′-tetramethoxy-4,4′-bis(2,3-epoxy-1-hydroxypropyl)biphenyl(12). Conclusion Compounds 1—5, are isolated from the genus Trigonostemon for the first time and compounds 6,7,9,11,12 are isolated from this plant for the first time.

关 键 词：剑叶三宝木 二萜类 香豆素类 补骨脂素 异补骨脂素 3 4 5-三甲氧基肉桂醛 

分 类 号：R284.1[医药卫生—中药学]