海南结核病患者利福平耐药基因突变情况分析  

Analysis of rifampicin resistance gene mutation in tuberculosis patients in Hainan

作　　者：赵秀娟 钟业腾[4] 陈灼霖 童子华 裴华 夏乾峰[1,2] ZHAO Xiu-juan;ZHONG Ye-teng;CHEN Zhuo-lin;TONG Zi-hua;PEI Hua;XIA Qian-feng(NHC Key Laboratory of Control of Tropical Diseases,School of Tropical Medicine and Laboratory Medicine,Hainan Medical University,Haikou,Hainan 571199,China;不详)

机构地区：[1]海南医科大学热带医学与检验学院热带病防治国家重点实验室,海南海口571199 [2]海南医学院热带医学与检验学院,海南海口571199 [3]海南医学院公共卫生学院,海南海口571199 [4]海南医学院第二附属医院,海南海口571199

出　　处：《中国卫生检验杂志》2021年第20期2473-2476,2481,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解海南结核病患者利福平rpo B耐药基因突变位点流行病学特征。方法收集2014年-2019年海南疑似结核病患者利福平耐药基因检测结果。计数资料采用频数和百分比进行统计描述,计量资料采用均数±标准差进行统计描述,组间差异性比较采用卡方检验或Fisher确切概率法,以P <0.05为差异有统计学意义。结果共检测到8类利福平耐药突变类型,其中最常见的耐药突变位点为rpo B531位点。随着时间推移,出现某些新型突变位点,如513CAA→CCA+516GAC→GTC联合突变位点。海口市、儋州市、文昌市和万宁市为耐药突变位点最常见的4个地区,分别占所有突变位点的19.5%、12.5%、10.0%和9.4%。此外,不同人群耐药突变位点有差异。结论结核病患者利福平耐药基因突变在不同时间、不同地区和不同人群中分布存在差异性。Objective To explore the epidemiological characteristics of rifampicin resistant mutations in tuberculosis patients in Hainan Province,China.Methods The information about rifampicin resistant mutations of suspected tuberculosis patients in Hainan from 2014 to 2019 was collected.Count data were described by frequency(percentage),and measurement data were described by mean±standard deviation respectively.The differences between different groups were compared by chi-square test or Fisher's exact probability.P<0.05 was considered statistically significant.Results Eight types of rifampicin resistant mutations were detected,among which rpob531 was the most common mutation.Over time,some new mutations appeared,such as 513CAA→CCA+516GAC→GTC mutation.Haikou,Danzhou,Wenchang and Wanning were the cities with the most rifampicin resistant mutations,accounting for 19.5%,12.5%,10.0%and 9.4%of all mutations,respectively.In addition,the mutations were different in different populations.Conclusion There were differences in the distribution of rifampicin resistant mutations in different time,different regions and different populations.

关 键 词：结核分枝杆菌 利福平突变位点 时间分布 地区分布 人群分布 

分 类 号：R446.5[医药卫生—诊断学]