生物响应性钆基磁共振成像造影剂的研究进展  

Recent Progress in Bio-responsive Gadolinium-based MRI Contrast Agent

作　　者：刘妍玥 吴勇杰 孙康[1] 陶可[1] LIU Yanyue;WU Yongjie;SUN Kang;TAO Ke(The State Key Lab of Metal Matrix Composites,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,P.R.China)

机构地区：[1]上海交通大学材料科学与工程学院金属基复合材料国家重点实验室,上海200240

出　　处：《影像科学与光化学》2021年第6期781-789,共9页Imaging Science and Photochemistry

摘　　要：临床上最常用的钆基磁共振造影剂(GBCA)在检测疾病时缺乏特异性而难以区分病灶。大量的研究关注于生物响应性造影剂的开发,使得磁共振(MR)信号强弱随生理或病理环境的变化而改变。本文回顾了目前生物响应性GBCA的3种设计理念,阐述了其提高弛豫率的具体途径及其在影像诊断上的应用,对生物响应性GBCA的发展做出了展望,并指出了其在临床转化过程中需解决的问题。The gadolinium-based contrast agent(GBCA),the most common contrast agent in clinical magnetic resonance(MR)imaging,lacks specificity when detecting diseases and thus makes it difficult to distinguish lesions.Many recent researches have focused on the development of bio-responsive contrast agents which can vary the intensity of MR signals with changes in physiological or pathological environment.This article reviews three current design concepts of bio-responsive GBCAs,expounds the specific methods of promoting relaxation rate and its application in imaging diagnosis,makes a prospect for the development of bio-responsive GBCA,and points out the problems to be solved in the conversion process for clinical application.

关 键 词：磁共振成像 钆基磁共振造影剂 生物响应性 弛豫率 疾病诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学]