多模态磁共振成像参数诊断轻中度新生儿缺氧缺血性脑病的价值  

The Value of Multimodal Magnetic Resonance Imaging Parameters in the Diagnosis of Mild to Moderate Neonatal Hypoxic-ischemic Encephalopathy

作　　者：刘璐 曲海新[1] 张丽娜 LIU Lu;QU Haixin;ZHANG Lina(Department of Neonatology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,P.R.China)

机构地区：[1]河北北方学院附属第一医院新生儿科,河北张家口075000

出　　处：《影像科学与光化学》2021年第6期860-864,共5页Imaging Science and Photochemistry

摘　　要：本研究探讨多模态磁共振成像(MRI)参数在新生儿缺氧缺血性脑病诊断中的价值。选取新生儿缺氧缺血性脑病轻度患儿54例,中度患儿34例,均给予MRI常规扫描、弥散张量成像及轻质子磁共振频谱扫描。中度患儿内囊后肢、丘脑分数各向异性(FA)值,N-乙酰天门冬氨酸(NAA)/肌酸(Cr)和NAA/胆碱(Cho)复合物明显低于轻度患儿(P<0.05);基底核区检测评分、分水岭区检测评分、内囊后肢FA值、丘脑FA值、NAA/Cr、NAA/Cho鉴别轻中度新生儿缺氧缺血性脑病的ROC曲线下面积均大于0.700(P<0.05),联合检测的灵敏性和特异性达到96.00%和98.00%。MRI多模态参数在新生儿缺氧缺血性脑病诊断中有较好的价值,在鉴别病情程度中有一定价值。This study was to investigate the value of multimodal magnetic resonance imaging(MRI)parameters in the diagnosis of neonatal hypoxic-ischemic encephalopathy.A total of 54 neonates with mild hypoxic-ischemic encephalopathy and 34 neonates with moderate hypoxic-ischemic encephalopathy were selected,and received conventional MRI scan,diffusion tensor imaging and light proton magnetic resonance spectrum scan.The fractional anisotropy(FA)values of posterior limb and thalamus,N-acetylaspartate(NAA)/creatine(Cr)and NAA/choline complex(Cho)in moderate group were significantly lower than those in mild group(P<0.05).The area under ROC curve of basal ganglia score,watershed score,FA value of posterior limb of internal capsule,FA value of thalamus,NAA/Cr and NAA/Cho in the differentiation of mild to moderate neonatal hypoxic-ischemic encephalopathy were all more than 0.700(P<0.05),while the sensitivity and specificity of combined detection reached 96.00%and 98.00%.MRI multimodal parameters have a good value in the diagnosis of neonatal hypoxic-is chemic encephalopathy,has a certain value in differentiating the degree of the disease.

关 键 词：多模态参数 磁共振成像 新生儿 缺氧缺血性脑病 

分 类 号：R722.1[医药卫生—儿科] R445.2[医药卫生—临床医学]