雷火灸治疗乳腺癌术后放化疗患者的气虚型癌因性疲乏的临床观察  

Clinical observation on the treatment of cancer-related fatigue caused by postoperative radiotherapy and chemotherapy of breast cancer with thunder fire moxibustion

作　　者：王力[1] 张寅斌[1] 杨荔[1] 王维玮 马倩倩 周玉生 张淑群[1] WANG Li;ZHANG Yinbin;YANG Li;WANG Weiwei;MA Qianqian;ZHOU Yusheng;ZHANG Shuqun(Oncology Department,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,Shanxi Province,China;School of Medicine,Xi'an Jiaotong University,Xi'an 710061,Shanxi Province,China)

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004 [2]西安交通大学医学部,陕西西安710061

出　　处：《世界临床药物》2021年第10期873-880,共8页World Clinical Drug

基　　金：陕西省重点研发计划项目(S2018-YF-YBSF-0316);西安交通大学第二附属医院院基金自由探索项目(2020YJ(ZYTS)624)。

摘　　要：目的评价雷火灸治疗乳腺癌术后放化疗患者气虚型癌因性疲乏的临床疗效和安全性。方法将符合入选标准的60例伴有癌因性疲乏的乳腺癌患者随机分为两组,每组30例。全部患者予常规护理,治疗组额外给予雷火灸治疗,日灸1次,疗程14 d,治疗结束后随访3个月并根据量表评分情况判定疗效。结果治疗前,两组患者Piper疲乏量表(PFS)、气虚证候评分、厌食/恶病质治疗功能评估量表(FAACT)、阿森斯失眠量表(AIS)、医院焦虑和抑郁量表(HADS)、卡氏功能状态(KPS)评分等的差异均无统计学意义(P>0.05);治疗结束后,雷火灸组各量表评分和气虚证候总分均低于治疗前,且FAACT评分、气虚证候评分和KPS评分的各个维度也均低于对照组;另外,依据PFS评分评估的雷火灸组有效率(93.33%)显著高于对照组(6.67%),以上差异均有统计学意义(P<0.05)。结论雷火灸能明显改善气虚型乳腺癌术后放化疗患者癌因性疲乏的临床症状和生存质量,疗效显著,未见不良反应,值得临床推广应用。Objective To evaluate the clinical efficacy and safety of thunder-fire moxibustion in treating Qi-deficiency cancer-related fatigue in breast cancer patients with postoperative radiotherapy and chemotherapy.Methods Sixty breast cancer patients with cancer-related fatigue who had undergone postoperative radiotherapy and chemotherapy were randomly divided into two groups:treatment group and control group,with 30 patients in each group.All patients were given routine nursing care,while the treatment group was additionally given thunder-fire moxibustion every day for 14 days.After treatment,all patients were followed up for 3 months and the curative effect was evaluated according to the scales.Results Before treatment,there was no difference in Piper fatigue scale(PFS),Qi-deficiency syndrome scores,functional assessment of anorexia/cachexia therapy(FAACT),Athens insomnia scale(AIS),hospital anxiety and depression scale(HADS)and Karnofsky performance status(KPS)score between the two groups(all P>0.05).After treatment,the scores of the various scales and the total scores of Qi-deficiency syndromes in the treatment group were lower than those before the treatment(P<0.05 or P<0.01).Then the FAACT score,Qi-deficiency syndromes scores and KPS scores were also lower than those in the control group(P<0.05).In addition,the effective rate of the treatment group was also significantly higher than the control group(93.33%vs 6.67%,P<0.05)according to the PFS scores.Conclusions Thunder fire moxibustion can significantly improve the clinical symptoms of cancer-related fatigue and quality of life in breast cancer patients with cancer-related fatigue and Qi-deficiency after radiotherapy and chemotherapy.The curative effect of thunder-fire moxibustion is significant,and there are no obvious adverse reactions.It is worthy of clinical application.

关 键 词：雷火灸 癌因性疲乏 乳腺癌 放化疗 气虚证 

分 类 号：R246.6[医药卫生—针灸推拿学]