搅拌及加晶种技术对药物结晶过程的影响  

Effect of Stirring and Seeding Technology on Crystallization

作　　者：唐云峰 武光 陈辉 薛富民[3] Tang Yunfeng;Wu Guang;Chen Hui;Xue Fumin(Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China;Shandong Provincial Institute of Regional Resources and Environmental Development,Jinan 250014,China;Shandong Analysis and Testing Center,Jinan 250014,China)

机构地区：[1]鲁南制药集团股份有限公司,山东临沂276006 [2]山东省区域资源与环境发展研究院,山东济南250014 [3]山东省分析测试中心,山东济南250014

出　　处：《山东化工》2021年第20期65-67,80,共4页Shandong Chemical Industry

基　　金：山东省重点研发计划(重大科技创新工程)(2020CXGC010506)。

摘　　要：结晶是一种重要的分离精制方法,具有产品纯度高、能耗低、操作条件温和等优势,在药物提纯中发挥着重要作用。结晶过程涉及复杂的晶体成核与生长过程,并受众多因素的影响。本文以此为出发点,主要综述了搅拌及添加晶种技术对结晶产品的晶型、粒度及粒度分布等方面的影响。Crystallization is an important separation and purification method,which has the advantages of high product purity,low energy consumption,and mild operating conditions.It plays an important role in drug purification.The crystallization process involves complex crystal nucleation and growth mechanisms,which are affected by many factors.The article mainly reviews the effects of stirring and seeding technology on the crystal form,particle size and particle size distribution of the crystalline product.

关 键 词：结晶 搅拌桨 搅拌强度 晶种 

分 类 号：TQ026.5[化学工程]