感冒灵颗粒HPLC指纹图谱  

HPLC Fingerprint of Ganmaoling Granule

作　　者：许荣煌 吴伟峰 唐小文 简荣超 邓煜然 孔令佳 林忠泽 Xu Ronghuang;Wu Weifeng;Tang Xiaowen;Jian Rongchao;Deng Yuran;Kong Lingjia;Lin Zhongze(TEYI Pharmaceutical Group Co.,Ltd.,Taishan 529200,China;School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529000,China)

机构地区：[1]特一药业集团股份有限公司,广东台山529200 [2]五邑大学生物科技与大健康学院,广东江门529000

出　　处：《山东化工》2021年第20期93-97,共5页Shandong Chemical Industry

摘　　要：目的:建立感冒灵颗粒的HPLC指纹图谱。方法:该药物的50%甲醇提取物的分析采用AcclaimTM 120 C_(18)(4.6×150 mm,5μm);流动相乙腈-0.1%磷酸,梯度洗脱;体积流量0.5 mL/min;检测波长330 nm;柱温30℃。结果:20批样品HPLC指纹图谱标定了13个共有峰,各指纹峰分离度较好;指认7个峰的归属,定性了1个峰。结论:该方法简便可行,稳定高效,可用于感冒灵颗粒的质量控制。In this paper,the 50%methanol extract of the drug was analyzed to establish the HPLC fingerprint of Ganmaoling granule.This method uses AcclaimTM 120 C_(18)(4.6×150mm,5μm)chromatographic column;other parameters are set as follows,the mobile phase is gradient elution acetonitrile-0.1%phosphoric acid,the rate of volume flow is 0.5 mL/min,330 nm is the detection wavelength,and column temperature is 30℃.Finally,HPLC fingerprints of 20 batches of samples were obtained,among which 13 common peaks were calibrated,and the resolution of each fingerprint peak was good;the attribution of 7 peaks was designated,and 1 peak was qualitative.The method is simple,feasible,stable and efficient,and can be used for quality control of Ganmaoling granule.

关 键 词：感冒灵颗粒 指纹图谱 HPLC 

分 类 号：R284.1[医药卫生—中药学]