IVIVR的建立方法及应用  

The method development and application of IVIVR

作　　者：梁雨婷 周琮杰 许华容[1] 李清[1] LIANG Yuting;ZHOU Congjie;XU Huarong;LI Qing(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2021年第10期1119-1126,共8页Journal of Shenyang Pharmaceutical University

基　　金：重大新药创制国家科技重大专项(2017ZX09101001);国家自然科学基金资助项目(81973464/H3203);2019年辽宁省“百千万人才工程”资助项目(A-37);辽宁特聘教授资助项目(李清);沈阳市中青年科技创新人才支持计划项目(RC190505)。

摘　　要：药品的体外特性和体内吸收过程之间的相关性一直是研究者的重点和难点,如何通过某些体外特征来评价药物在体内的药代动力学过程对于药品的质量控制有重大意义。体内体外关系(IVIVR)是相对于体内外相关性(IVIVC)提出的一种预测性的数学模型,旨在建立药物制剂的体内生物学过程和体外释放特性之间的关系。本文介绍了IVIVC和IVIVR的建立流程,系统总结了IVIVC和IVIVR的异同点,重点讨论了近年来IVIVR的研究进展。Objective The correlation between the in vitro properties and in vivo absorption process of drugs has always been the focus and difficulty of researchers.It is beneficial for the quality control of drugs that how to evaluate the pharmacokinetic process of drugs in vivo through certain in vitro characteristics.In vitro/in vivo relationship(IVIVR)is a predictive mathematical model proposed by in vitro/in vivo correlation(IVIVC),which aims to establish the relationship between the in vivo biological process of pharmaceutical preparations and the in vitro release characteristics.This article introduces the establishment of IVIVC and IVIVR,and summarizes the similarities and differences between IVIVC and IVIVR systematically,focusing on the research progress of IVIVR in recent years.

关 键 词：IVIVR IVIVC 体外释放特性 体内生物学过程 

分 类 号：R917[医药卫生—药物分析学]