金钱松化学成分及药理活性研究进展  

Research progress on chemical constituents and pharmacological activities of Pseudolarix amabilis

作　　者：李斌[1] 段淑莉 王思成 曾妮 姚清颖 姚旺 张在其 彭彩云[1] 王炜[1] LI Bin;DUAN Shu-li;WANG Si-cheng;ZENG Ni;YAO Qing-ying;YAOWang;ZHANG Zai-qi;PENG Cai-yun;WANG Wei(TCM and Ethnomedicine Innovation&Development International laboratory,Sino-Pakistan TCM&Ethnomedicine International Cooperation Base,School of pharmacy,Hunan University of Chinese Medicine,Changsha,410208,China;Jinan University,Guangzhou,510632,China;Chukochen Honors College,Zhejiang University,Hangzhou,310012,China;Hunan Provincial Key Laboratory of Dong Medicine,Hunan University of Medicine,Huaihua,418000,China)

机构地区：[1]湖南中医药大学药学院中医药民族医药国际联实验室中巴医药民族医药研究国际合作基地,湖南长沙410208 [2]暨南大学,广东广州510632 [3]浙江大学竺可桢学院,浙江杭州310012 [4]湖南医药学院侗医药研究湖南省重点实验室,湖南怀化418000

出　　处：《中草药》2021年第19期6096-6110,共15页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(81703819);湖南省自然科学基金项目(2020JJ4463,2020JJ4064);侗医药研究湖南省重点实验室(2015TP1020-02);侗医药研究湖南省重点实验室平台建设(2017CT5025);大学生研究性学习和创新性实验计划项目(S202010541039)。

摘　　要：金钱松Pseudolarix amabilis为松科(Pinaceae)金钱松属植物,为我国特有树种。其根皮或近根皮可作为药用,名为土荆皮,其性辛、温;归肺、脾经,具有杀虫、疗癣、止痒作用,可用于疥癣瘙痒,在我国民间作为药用已有悠久历史。迄今从金钱松分离出215个化合物,主要为二萜类、三萜类、倍半萜类、苯丙素类、黄酮类、甾醇类及其它化学成分。现代药理研究表明金钱松具有抗菌、抗肿瘤、抗生育、抗血管生成等活性。就金钱松的化学成分及药理作用方面进行总结,以期为金钱松深入的研究开发及利用提供科学的依据。Pseudolarix amabilis(J. Nelson) Rehder is a Pseudolarix plant of the Pinaceae family and is a unique tree species in China. The root bark of Pseudolarix amabilis can be used for medicine, called Tu-jing-pi, and it is pungent in taste, warm in nature and attributive to the lung and spleen meridians, it has the function of insecticide and relieving itching, and can be used to treat tinea disease, and it has a long history as a folk medicine in China. Up to now, 215 compounds have been isolated from Pseudolarix amabilis, which mainly contain diterpenes, triterpenes, sesquiterpenes, phenylpropanes, flavonoids, sterols and other chemical constituents. Modern pharmacological studies have shown that Pseudolarix amabilis has bioactivities such as: antibacterial, anti-tumor, anti-fertility, anti-angiogenesis et al. This review summarizes the chemical constituents and pharmacological activities of Pseudolarix amabilis, in order to provide scientific basis for further research, development and utilization of Pseudolarix amabilis.

关 键 词：金钱松 土荆皮 土荆皮乙酸 抗菌 抗肿瘤 

分 类 号：R286[医药卫生—中药学]