乌司他汀对急性心肌梗死冠脉介入治疗术后内皮功能及炎性因子的影响  

作　　者：杨启岭 段卡丹 邱梅红 张鲜鲜 

机构地区：[1]郑州大学附属洛阳中心医院心内科,471000

出　　处：《中国疗养医学》2022年第1期88-91,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探讨乌司他汀对急性心肌梗死经皮冠状动脉介入术(PCI)术后内皮功能及心型脂肪酸结合蛋白(H-FABP)、钙卫蛋白(S100AB)的影响。方法选择2018年6月至2019年12月在郑州大学附属洛阳中心医院接受治疗的106例急性心肌梗死患者,采用抽签法分为观察组(n=54)和对照组(n=52)。对照组术后给予氯吡格雷治疗,观察组术后给予乌司他汀治疗。比较两组患者的心功能、血流介导的血管扩张功能(FMD)、非内皮依赖性舒张功能(NMD)、H-FABP、S100AB水平变化情况、心脏不良事件发生情况及药物不良反应发生情况。结果治疗后,两组左室舒展末期内径(LVDs)、左室收缩末期内径(LVDd)显著降低,且观察组均低于对照组,左室射血分数(LVEF)水平均显著升高,且观察组显著高于对照组(P<0.05);治疗前,两组内皮功能水平差异无统计学意义;治疗后,两组FMD、NMD均显著升高,且观察组均高于对照组(P<0.05);治疗前,两组H-FABP、S100AB水平差异无统计学意义;治疗后,两组H-FABP、S100AB均显著降低,且观察组均低于对照组(P<0.05);观察组心脏不良事件总发生率为5.56%,显著低于对照组的26.92%(P<0.05);两组不良反应总发生率分别为7.41%、13.46%(P>0.05)。结论在急性心肌梗死PCI术后给予乌司他汀效果显著,可有效改善患者内皮功能及H-FABP、S100AB水平。Objective To investigate the effects of Urinastatin on endothelial function,heart-type fatty acid binding protein(H-FABP)and calprotectin(S100AB)after percutaneous coronary intervention(PCI)in acute myocardial infarction.Methods A total of 106 patients with acute myocardial infarction treated in Luoyang Central Hospital affiliated to Zhengzhou University from June 2018 to December 2019 were selected and divided into observation group(n=54)and control group(n=52)by lottery.The control group was treated with Clopidogrel and the observation group was treated with Urinastatin.Cardiac function,blood flow-mediated dilation(FMD),Nitroglycerin-mediated dilation(NMD),H-FABP and S100AB levels,incidence of cardiac adverse events and adverse drug reactions were compared between the two groups.Results After treatment,left ventricular end-systolic dimension(LVDs)and left ventricular end-diastolic dimension(LVDd)of the two groups were significantly decreased,and the observation group was lower than the control group.The levels of left ventricular ejection fraction(LVEF)were increased significantly,and the observation group was significantly higher than the control group(P<0.05);Before treatment,there was no significant difference in endothelial function between the two groups;After treatment,FMD and NMD increased significantly in the two groups,and the observation group was higher than the control group(P<0.05);Before treatment,there was no significantdifference in the levels of H-FABP and S100AB between the two groups;After treatment,H-FABP and S100AB in the two groups were significantly decreased,and the observation group was lower than the control group(P<0.05);The total incidence of adverse cardiac events in the observation group was 5.56%,significantly lower than 26.92%in the control group(P<0.05);The total incidence of adverse reactions in the two groups were 7.41%and 13.46%respectively(P>0.05).Conclusion Urinastatin is effective after PCI for acute myocardial infarction,which can effectively improve the endothelial funct

关 键 词：乌司他汀 急性心肌梗死 经皮冠状动脉介入术 内皮功能 心型脂肪酸结合蛋白 钙卫蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]