Isometric exercise promotes arteriogenesis in rats after myocardial infarction  

作　　者：Xintong Zhang Yu Zheng Canru Geng Juntao Guan Lu Wang Xiu Zhang Yihui Cheng Jian'an Li Xiao Lu 

机构地区：[1]Department of Rehabilitation Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Department of Rehabilitation Medicine,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou,Jiangsu 215000,China.

出　　处：《The Journal of Biomedical Research》2021年第6期436-447,共12页生物医学研究杂志（英文版）

基　　金：supported by the research grants from the National Natural Science Foundation of China(Grant No.8177244,No.81902288,and No.82072546);Nanjing Municipal Science and Technology Bureau(Grant No.2019060002).

摘　　要：Isometric exercise(IE)is a promising intervention of noninvasive revascularization in patients with acute myocardial infarction(AMI).This study aimed to investigate the impact and mechanisms of IE training on arteriogenesis in AMI.Male Sprague-Dawley rats were randomly assigned into the sham-operation group(SO),myocardial infarction(MI)group,and 13 IE subgroups treated according to training intensity,frequency,duration,or monocyte chemoattractant protein-1(MCP-1),or/and fibroblast growth factor-2(FGF-2)inhibitors for eight weeks.Our results demonstrated that the IE group achieved superior improvement compared with the MI group in terms of left ventricular ejection fraction(LVEF),myocardial infarction size(MIS),arterial density(AD),monocytes(MNCs),smooth muscle cells(SMCs),endothelial cells(ECs),relative collateral blood flow(RCBF),MCP-1,and FGF-2 at the endpoint.Positive correlations between MCP-1 and MNCs,MNCs and FGF-2,FGF-2 and SMCs,SMCs and AD,as well as AD and RCBF were observed.This study demonstrated that with MI of 100%load 20 times daily for eight weeks,the arteriogenesis was improved,which may be attributed to the recruitment of MNCs and SMCs in remote ischemic myocardium caused by increases in MCP-1 and FGF-2 expression.

关 键 词：isometric exercise training ARTERIOGENESIS acute myocardial infarction monocyte chemoattractant protein-1 fibroblast growth factor-2 

分 类 号：R49[医药卫生—康复医学]