妊娠期肝内胆汁淤积症患者的围产儿结局分析  

Perinatal outcome of patients with intrahepatic cholestasis of pregnancy

作　　者：孙晋萍[1] 樊庆泊[2] 翟建军[1] Sun Jinping;Fan Qingbo;Zhai Jianjun(Department of Obstetrics and Gynecology,Beijing Tongren Hospital,Capital Medical University,Beijing 100176 China;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院妇产科,100176 [2]北京协和医院妇产科,100730

出　　处：《中国医药》2021年第11期1705-1707,共3页China Medicine

摘　　要：目的探讨妊娠期肝内胆汁淤积症(ICP)患者的围产儿结局。方法收集2017年1月至2020年1月在首都医科大学附属北京同仁医院分娩的160例ICP患者的临床资料(观察组),同期分娩的180例正常产妇的临床资料(对照组)。比较2组围产儿结局,包括羊水污染、胎儿窘迫、新生儿窒息、早产、围产儿死亡等情况。结果观察组羊水污染、胎儿窘迫、新生儿窒息、早产发生率明显高于对照组[37.5%(60/160)比14.4%(26/180)、21.2%(34/160)比7.8%(14/180)、10.0%(16/160)比3.9%(7/180)、28.1%(45/160)比8.3%(15/180)],差异均有统计学意义(均P<0.05);观察组与对照组围产儿死亡率差异无统计学意义[0.6%(1/160)比0(0/160)](P>0.05)。结论ICP虽然是良性疾病,但对围产儿有严重的不良影响,可导致不良预后,甚至发生不可预测的胎儿宫内死亡。对ICP孕妇应该积极处理,加强胎儿监护,适时终止妊娠,可改善妊娠结局,改善围产儿预后。Objective To explore the perinatal outcome of patients with intrahepatic cholestasis of pregnancy(ICP).Methods The clinical data of 160 ICP patients delivered in Beijing Tongren Hospital,Capital Medical University from January 2017 to January 2020 were collected(observation group)and 180 normal pregnant women delivered in the same period were collected(control group).The perinatal outcome of the two groups were compared,including amniotic fluid pollution,fetal distress,neonatal asphyxia,premature delivery and perinatal death.Results The incidences of amniotic fluid pollution,fetal distress,neonatal asphyxia and premature delivery in the observation group were significantly higher than those in the control group[37.5%(60/160)vs14.4%(26/180),21.2%(34/160)vs 7.8%(14/180),10.0%(16/160)vs 3.9%(7/180),28.1%(45/160)vs 8.3%(15/180)](all P<0.05);there was no significant difference in perinatal mortality between observation group and control group[0.6%(1/160)vs 0(0/160)](P>0.05).Conclusions Although ICP is a benign disease,it has serious adverse effects on perinatal infants,which can lead to poor prognosis,even unpredictable intrauterine death.ICP pregnant women should be actively treated,strengthening fetal monitoring,terminating pregnancy in time,so as to improve pregnancy outcome and perinatal prognosis.

关 键 词：妊娠期肝内胆汁淤积症 早产 胎儿窘迫 羊水胎粪污染 新生儿窒息 

分 类 号：R714.25[医药卫生—妇产科学]