PI3K/AKT/mTOR信号通路与线粒体稳态在疾病治疗中的作用  

Roles of PI3K/Akt/mTOR signaling pathway and mitochondrial homeostasis in treatment of some diseases

作　　者：胡晓青[1] 于慧美[1] 沈璐妍 杨一萌 陈秋艳 董德录 孙连坤[1] HU Xiao-qing;YU Hui-mei;SHEN Lu-yan;YANG Yi-meng;CHEN Qiu-yan;DONG De-lu;SUN Lian-kun(Department of Pathophysiology,College of Basic Medical Sciences,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学基础医学院病理生理学系,吉林长春130021

出　　处：《中国病理生理杂志》2021年第11期2072-2076,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81772794,No.81672948,No.81472419)。

摘　　要：在不同环境下,细胞需要协调多种信号通路而有组织地适应不断变化的内外环境,以维持细胞稳态。鉴于疾病的复杂性,需要我们向整体研究的思路转变,以重要信号通路为立足点,深入了解疾病背景下信号通路在维系细胞稳态中的调控机制,为药物靶向治疗提供更多的理论基础。Phosphatidylinositiol 3-kinase(PI3 K)/protein kinase B(PKB/AKT)/mammalian target of rapamycin(mTOR) signaling pathway is a key signaling pathway that regulates cell growth,proliferation,differentiation,apoptosis and metabolism.It has been found that this signaling pathway is closely related to the occurrence and development of cancer,neurodegenerative diseases and many other diseases.Although targeting PI3 K/AKT/mTOR signaling pathway has been applied in anti-tumor therapy,increasing studies have found that the inhibitors of this signaling pathway up-regulate mitochondrial function through reprograming to reduce their anti-tumor effects.On the other hand,abnormal activation of PI3 K/AKT/mTOR signaling pathway during aging may lead to decreased mitochondrial homeostasis and induce cellular senescence.Therefore,the regulatory mechanism of mitochondrial homeostasis is an important factor to influence the effect of PI3 K/AKT/mTOR signaling pathway-targeted therapy on the diseases.In this article,we review the current knowledge on the roles of PI3 K/AKT/mTOR signaling pathway and their targets in some diseases,focusing on the interaction between PI3 K/AKT/mTOR signaling pathway and mitochondrial homeostasis.

关 键 词：PI3K/AKT/mTOR信号通路 线粒体稳态 癌症 细胞衰老 靶向治疗 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R363[医药卫生—基础医学]