间充质干细胞来源的外泌体对肺损伤的治疗作用及其潜在机制  

Therapeutic effect of mesenchymal stem cell-derived exosomes on lung injury and its mechanism

作　　者：宋晓婉 梁璐 SONG Xiao-wan;LIANG Lu(Health&Biotech(Tianjin)Stem Cell Research Institute Co.Ltd,Tianjin 301700,China;Tianjin Bion Biotech Co.Ltd,Tianjin 300318,China)

机构地区：[1]汉氏联合(天津)干细胞研究院有限公司,天津301700 [2]天津百恩生物科技有限公司,天津300318

出　　处：《中国病理生理杂志》2021年第11期2107-2112,共6页Chinese Journal of Pathophysiology

基　　金：天津市高端兽药先进制造科技重大专项(No.17ZXGSNC00040)。

摘　　要：间充质干细胞(mesenchymal stem cell,MSC)是再生医学领域中应用最广泛的干细胞[1]。MSC具有抗炎、免疫调节、损伤修复、促血管新生及抗纤维化等生物学特性。目前MSC在肺损伤疾病中的治疗研究越来越多,实验数据表明MSC能够明显降低肺部炎症反应,减少肺组织损伤[2]。越来越多的研究表明MSC发挥治疗作用的主要机制是旁分泌作用,间充质干细胞来源的外泌体(mesenchymal stem cell-de-rived exosomes,MSC-EXOs)作为其主要的旁分泌组分,是其发挥生物学功效的关键。本文就MSC-EXOs的生物学特性及其对急性肺损伤(acute lung injury,ALI)和其他肺损伤疾病的治疗作用和潜在机制做一综述。Mesenchymal stem cell-derived exosomes(MSC-EXOs) are important messengers of intercellular communication,being involved in regulating many physiological and pathological processes,such as immune response,apoptosis,angiogenesis,and inflammatory response.This article reviews the therapeutic effect of MSC-EXOs in lung injury and underlying mechanism.MSC-EXOs alleviate acute lung injury through immune regulation,inhibition of apoptosis of alveolar epithelium and endothelial cells,improvement of alveolar fluid clearance rate,antibacterial effect and inhibition of pulmonary fibrosis.In addition,MSC-EXOs have therapeutic effects on other lung diseases such as pulmonary hypertension,bronchopulmonary dysplasia and allergic airway inflammation.At present,most researches on MSC-EXOs are in preclinical stage,and more clinical data are needed to verify its efficacy.With the deepening and comprehensive research,MSC-EXOs,as a stem cell-free treatment method,may become an effective alternative to stem cell therapy in the future.

关 键 词：间充质干细胞 外泌体 肺损伤 肺炎性疾病 肺纤维化 

分 类 号：R563[医药卫生—呼吸系统] R363[医药卫生—内科学]