血清转化生长因子-β_(1)、血管内皮生长因子对子宫内膜息肉患者宫腔镜术后复发的影响  

Effect of Serum Transforming Growth Factor-β_(1) and Vascular Endothelial Growth Factor on Recurrence After Hysteroscopy in Patients with Endometrial Polyps

作　　者：吴会娜 段晓怡 吕田甜[3] WU Huina;DUAN Xiaoyi;Lü Tiantian(Department of Obstetrics and Gynecology,Zhoukou Yongshan Hospital,Zhoukou 461300,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Obstetrics,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]周口永善医院妇产科,河南周口461300 [2]河南科技大学第一附属医院妇产科,河南洛阳471000 [3]河南科技大学第二附属医院产科,河南洛阳471000

出　　处：《河南医学研究》2021年第33期6214-6217,共4页Henan Medical Research

摘　　要：目的分析血清转化生长因子-β_(1)(TGF-β_(1))、血管内皮生长因子(VEGF)对子宫内膜息肉患者宫腔镜术后复发的影响。方法选取2018年10月至2020年10月就诊于周口永善医院的32例子宫内膜息肉患者作为研究对象。宫腔镜术前,检测所有患者血清TGF-β_(1)、VEGF水平,并在术后进行6个月的跟踪随访,记录宫腔镜术后子宫内膜息肉复发情况,并分析血清TGF-β_(1)、VEGF水平对子宫内膜息肉患者宫腔镜术后复发的影响。结果 64例子宫内膜息肉患者中,有15例复发,占比为23.44%(15/64);复发组血清TGF-β_(1)、VEGF水平高于未复发组,差异有统计学意义(P<0.05);经多项logistic回归分析显示,血清TGF-β_(1)、VEGF水平升高是导致子宫内膜息肉患者宫腔镜术后复发的影响因素(OR>1,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示血清TGF-β_(1)、VEGF单独及联合预测子宫内膜息肉患者宫腔镜术后复发的曲线下面积(AUC)均>0.7,均有一定预测价值,且以联合预测价值最佳。结论子宫内膜息肉患者宫腔镜术后复发风险较高,而血清TGF-β_(1)、VEGF水平升高是导致子宫内膜息肉患者宫腔镜术后复发的影响因素。Objective To analyze the effect of serum transforming growth factor-β_(1)(TGF-β_(1))and vascular endothelial growth factor(VEGF)on recurrence of patients with endometrial polyps after hysteroscopy.Methods A total of 32 patients with endometrial polyps treated in Zhoukou Yongshan Hospital from October 2018 to October 2020 were selected as the research subjects.The levels of serum TGF-β_(1) and VEGF of all patients were measured before hysteroscopy.They were followed up for 6 months after operation.The recurrence of endometrial polyps after hysteroscopy was recorded,and the effect of serum TGF-β_(1) and VEGF levels on the recurrence of patients with endometrial polyps after hysteroscopy was analyzed.Results Among 64 cases of patients with endometrial polyps,15 cases recurred,accounting for 23.44%(15/64).The levels of serum TGF-β_(1) and VEGF in recurrence group were higher than those in non recurrence group,and the difference was statistically significant(P<0.05).Multiple logistic regression analysis showed that the increased levels of serum TGF-β_(1) and VEGF were the influencing factors for the recurrence of patients with endometrial polyps after hysteroscopy(OR>1,P<0.05).The receiver operating characteristic(ROC)curve was drawn,and the results showed that the area under the curve(AUC)of serum TGF-β_(1) and VEGF alone and in combination to predict the recurrence of endometrial polyps after hysteroscopy were>0.7.All had certain prediction value,and the joint prediction value was the best.Conclusion Patients with endometrial polyps have a higher risk of recurrence after hysteroscopy,the increase of serum TGF-β_(1) and VEGF levels is the influencing factor of postoperative recurrence in patients with endometrial polyps.

关 键 词：子宫内膜息肉 宫腔镜息肉切除术 复发 血清转化生长因子 血管内皮生长因子 

分 类 号：R711.74[医药卫生—妇产科学]