血清D-二聚体、白细胞介素-1β与B型主动脉夹层患者覆膜支架腔内修复术治疗预后的关系  

Relationship Between Serum D-Dimer, Interleukin-1β Levels and Prognosis of Patients with Type B Aortic Dissection Treated with Endovascular Aortic Repair

作　　者：魏玉鑫 WEI Yuxin(Department of Cardiac Macrovascular Surgery,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院心脏大血管外科,河南南阳473000

出　　处：《河南医学研究》2021年第33期6231-6234,共4页Henan Medical Research

摘　　要：目的探讨血清D-二聚体(D-D)、白细胞介素-1β(IL-1β)在B型主动脉夹层(TBAD)患者中的表达,并分析二者与患者覆膜支架腔内修复术(EVAR)治疗预后的关系。方法选取2019年4月至2021年4月南阳市第一人民医院收治的102例TBAD患者为研究对象,患者均接受EVAR治疗,术后均随访3个月。随访3个月时,进行主动脉CT血管造影检查,评估患者预后情况,并分为预后不良组和预后良好组;术前检测患者血清D-D、IL-1β水平,询问并记录患者基线资料,分析血清D-D、IL-1β水平与TBAD患者接受EVAR治疗预后的关系。结果 102例TBAD患者经评估,18例预后不良,占17.65%;预后不良组术前血清D-D、IL-1β水平高于预后良好组(P<0.05);组间其他基线资料比较,差异无统计学意义(P>0.05)。经logistic回归分析,结果显示,术前血清D-D、IL-1β过表达与TBAD患者接受EVAR治疗预后不良有关(P<0.05)。结论术前血清D-D、IL-1β过表达与TBAD患者接受EVAR治疗预后不良有关。Objective To investigate the expression of serum D-dimer(D-D)and interleukin-1β(IL-1β)levels in patients with type B aortic dissection(TBAD),and to analyze the relationship between them and the prognosis of patients treated with endovascular aortic repair(EVAR).Methods A total of 102 patients with TBAD treated in Nanyang First People’s Hospital from April 2019 to April 2021 were selected as the research subjects.All patients were treated with EVAR in the hospital,and all patients accepted 3 months of follow-up after operation.At 3 months of follow-up,CT angiography of aorta was performed,and the prognosis of patients was evaluated and all patients were divided into poor prognosis group and good prognosis group.The levels of serum D-D and IL-1βof patients were measured before operation.The baseline data of patients were asked and recorded,and the relationship between the levels of serum D-D and IL-1βand the prognosis of TBAD patients treated with EVAR was analyzed.Results Among 102 patients with TBAD after assessment,18 cases had poor prognosis,accounting for 17.65%.The levels of serum D-D and IL-1βbefore operation in poor prognosis group were higher than those in good prognosis group(P<0.05).There was no statistical significant difference in other baseline data between the two groups(P>0.05).Through logistic regression analysis,the results showed that overexpression of serum D-D and IL-1βbefore operation was related to the poor prognosis of TBAD patients treated with EVAR(P<0.05).Conclusion The overexpression of preoperative serum D-D and IL-1βis related to the poor prognosis of TBAD patients treated with EVAR.

关 键 词：B型主动脉夹层 覆膜支架腔内修复术 D-二聚体 白细胞介素-1Β 

分 类 号：R543.1[医药卫生—心血管疾病]