血清FGF2、尿肝素结合蛋白在产后盆底肌力减退伴尿路感染中表达及盆底肌功能训练干预效果  

Expression of Serum FGF2,Heparin Binding Protein in Urine in Postpartum Pelvic Floor Muscle Hypofunction with Urinary Tract Infection and the Intervention Effect of Pelvic Floor Muscle Function Training

作　　者：阴敏[1] 唐亮[1] 姜百灵 张丛敏 刘颖[3] 刘静 周薇 Yin Min;Tang Liang;Jiang Bailing;Zhang Congmin;Liu Ying;Liu Jing;Zhou Wei(Department of Perinatal Health,Panzhihua Maternal and Child Health Hospital,Panzhihua 617000,Sichuan Province,China;不详)

机构地区：[1]攀枝花市妇幼保健院围产保健科,四川省攀枝花市617000 [2]崇州市妇幼保健计划生育服务中心妇产科,四川省成都市611230 [3]成都市第五人民医院妇产科,四川省成都市611130

出　　处：《中国病案》2021年第10期109-112,共4页Chinese Medical Record

摘　　要：目的探究血清成纤维细胞生长因子2、尿肝素结合蛋白在产后盆底肌力减退伴尿路感染中表达,明确盆底肌功能训练干预效果,为临床防治产后盆底肌力减退伴尿路感染提供参考依据。方法选取2016年10月1日-2020年9月30日某院收治的108例产后盆底肌力减退伴尿路感染患者作为研究对象,根据尿路感染评分划分为评分高组20例和评分低组88例,统计两组血清成纤维细胞生长因子2、尿肝素结合蛋白水平,分析其与尿路感染评分相关性。同时给予108例产后盆底肌减退伴尿路感染患者抗感染治疗+盆底肌功能训练,比较治疗前、治疗3个月后血清成纤维细胞生长因子2、尿肝素结合蛋白水平、盆底肌功能评分,分析两者相关性。结果评分高组FGF2(1.08±0.22)pg/ml、U-HBP(142.69±38.17)ng/ml高于评分低组(0.71±0.17)pg/ml、(97.57±27.51)ng/ml,差异具有统计学意义,P<0.05,FGF2、U-HBP与产后盆底肌力减退伴尿路感染患者尿路感染评分呈正相关(P<0.001)。108例产后盆底肌力减退伴尿路感染患者治疗3个月后FGF2(0.43±0.20)pg/ml、U-HBP(62.38±19.65)ng/ml水平低于治疗前(0.89±0.45)pg/ml、(120.13±32.09)ng/ml,差异具有统计学意义,P<0.05;患者治疗3个月后PFDI-20得分为(107.52±12.99)分,低于治疗前得分(210.77±21.34)分,差异具有统计学意义,P<0.05。FGF2、U-HBP水平与产后盆底肌力减退伴尿路感染患者PFDI-20、CARDI-8、UDI-6、POPDI-6评分呈正相关,P<0.05。结论血清成纤维细胞生长因子2、尿肝素结合蛋白参与产后盆底肌力减退伴尿路感染发生发展过程,给予盆底肌功能训练能有效改善盆底肌功能,下调血清成纤维细胞生长因子2、尿肝素结合蛋白水平。Objective To investigate the expression of serum fibroblast growth factor 2(FGF2)and heparin binding protein in urine(U-HBP)in postpartum pelvic floor muscle hypofunction with urinary tract infection,to clarify the effect of pelvic floor muscle function training intervention,and provide a reference for clinical prevention and treatment of postpartum pelvic floor muscle hypofunction and urinary tract infection.Methods 108 patients with postpartum pelvic floor muscle hypofunction and urinary tract infection who were admitted to a hospital from October 1,2016 to September 30,2020 were selected as the research objects.According to the urinary tract infection score,they were divided into high score group(n=20)and low score group(n=88).The levels of FGF2 and U-HBP in the two groups were counted and their correlation with the urinary tract infection score was analyzed.At the same time,108 patients with postpartum pelvic floor muscle hypotrophy and urinary tract infection were given anti-infection treatment+pelvic floor muscle function training.The FGF2,U-HBP levels and pelvic floor muscle function(PFDI-20 score)were compared before and after 3 months of treatment,and the correlation between the two was analyzed.Results The levels of FGF2(1.08±0.22)pg/ml and U-HBP(142.69±38.17)ng/ml in the high score group were higher than those in the low score group(0.71±0.17)pg/ml,(97.57±27.51)ng/ml(P<0.05).FGF2 and U-HBP were positively correlated with the urinary tract infection score of patients with postpartum pelvic floor muscle hypofunction and urinary tract infection(P<0.05).The FGF2(0.43±0.20)pg/ml,U-HBP levels(62.38±19.65)ng/ml and PFDI-20(107.52±12.99),CARDI-8,UDI-6,POPDI-6 scores of 108 patients with postpartum pelvic hypofunction and urinary tract infection after 3 months of treatment were lower than those before treatment FGF2(0.89±0.45)pg/ml,U-HBP(120.13±32.09)ng/ml,PFDI-20(210.77±21.34)(P<0.05).The levels of FGF2 and U-HBP were positively correlated with the scores of PFDI-20,UDI-6,POPDI-6 and CARDI-8 in patie

关 键 词：产后盆底肌力减退 尿路感染 盆底肌功能训练 FGF2 U-HBP PFDI-20评分 

分 类 号：R714.6[医药卫生—妇产科学]