IL-2、IL-12、IL-13、MIP-1与急性冠脉综合征痰瘀互结证的相关性研究  

IL-2、IL-12、IL-13、MIP-1 Related to Acute Coronary Syndrome with Syndrome of Intermingled Phlegm and Blood Stasis

作　　者：潘秋霞 胡镜清[2] PAN Qiu-xia;HU Jing-qing(PLA Strategic Support Force Characteristic Medical Center,Beijing 100101,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]战略支援部队特色医学中心,北京100101 [2]中国中医科学院中医基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2021年第10期1584-1587,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：中国中医科学院中医基础理论研究所第十三批自主课题(YZ-1880)-加味四妙勇安汤降低急性冠脉综合征“炎症负荷”的机制;佛山市科技创新项目(中医药领域先行先试科技攻关专项)(2020001005585)-痰瘀互结相关慢病社区防控关键共性技术与应用研究。

摘　　要：目的:探索白介素2(IL-2)、白介素13(IL-13)、白介素12(IL-12)、巨噬细胞炎性蛋白1(MIP-1)等炎性相关细胞因子与急性冠脉综合征(ACS)痰瘀互结证的相关性。方法:收集ACS患者和健康志愿者血样分为健康组(12例)、痰瘀互结证组(10例)和非痰瘀互结证组(13例),检测血清样中IL-2、IL-12、IL-13、MIP-1等含量。结果:痰瘀互结证组外周血中IL-2、IL-12、IL-13、IL-17、MIP-1含量均明显高于健康对照组和非痰瘀互结证组,与健康对照组比较,ACS痰瘀互结证组和非痰瘀互结证组趋化因子(CC基元)配体5(CCL5)的含量均显著降低,IL-18的含量均明显升高,但CCL5和IL-18在ACS痰瘀互结证组和非痰瘀互结证组中的含量比较差异无统计学意义。结论:IL-2、IL-12、IL-13、MIP-1与ACS痰瘀互结证密切相关。Objective:To explore the relationship between 11 cytokines and acute coronary syndrome(ACS)with syndrome of intermingled phlegm and blood stasis(PB).Methods:Serum samples of ACS patients and the healthy were collected and divided into 3 groups:the healthy group(12 samples),the PB group(10 samples),and the non-phlegm and non-blood stasis syndrome(N-PB)group(13 samples).The expression of 11 cytokines were detected.Results:IL-2,IL-12,IL-13,IL-17 and MIP-1 levels in the PB group were significantly higher than those in the healthy and the N-PB groups.Compared with the healthy group,the CCL5 levels in the PB and the N-PB groups were significantly decreased;and the IL-18 levels in the PB and N-PB groups were significantly increased.However,there was no significant difference in CCL5,IL-18 levels between the PB group and the N-PB group.Conclusions:IL-2,IL-12,IL-13,MIP-1 are related to ACS with syndrome of intermingled phlegm and blood stasis.

关 键 词：急性冠脉综合征 痰瘀互结证 炎症 白介素2 白介素12 白介素13 巨噬细胞炎性蛋白-1 

分 类 号：R285.5[医药卫生—中药学]