Ca^(2+)与类风湿关节炎的相关性研究  

Correlation between Ca^(2+)and Rheumatoid Arthritis

作　　者：杨越 李露 崔玮璐 曹炜[1] YANG Yue;LI Lu;CUI Wei-lu;CAO Wei(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医基础医学杂志》2021年第10期1602-1605,1618,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点研发计划资助项目(2018YFC1705500)-类风湿性关节炎中医分期防治方案的优化及循证评价研究。

摘　　要：类风湿关节炎疾病病程中形成的病理性滑膜炎、血管翳在早期主要引起患者关节疼痛、肿胀以及僵硬等症状,但在疾病发展到病程后期,炎症的侵蚀性损害导致的关节软骨和骨的破坏可能使患者出现关节畸形和功能丧失。Ca^(2+)不仅在骨的生成中有至关重要的作用,同时也参与类风湿关节炎病程后期发生的骨质破坏。众多的科学研究还发现,Ca^(2+)与类风湿关节炎的发病机制息息相关,其可能在类风湿关节炎的发生发展中充当重要媒介。本文从Ca^(2+)与骨代谢、钙结合蛋白、Ca^(2+)稳态角度探索Ca^(2+)在类风湿关节炎发病机制中的不同作用,寻找二者间的相关性,为类风湿关节炎的诊断以及治疗寻找更多可能存在的新策略,并结合中药调控Ca^(2+)缓解类风湿关节炎病情的相关研究以证实二者间的关联。Pathologic synovitis and pannus formed in the course of rheumatoid arthritis disease mainly cause pain,swelling,stiffness and other symptoms of the patient's joints in the early stage.But in the later stage of the disease,the destruction of articular cartilage and bone caused by erosive inflammation may lead to joint deformity and loss of function.Ca^(2+)not only plays a crucial role in bone formation,but also participates in bone destruction in the later stages of rheumatoid arthritis.Numerous scientific studies have found that Ca^(2+)is closely related to the pathogenesis of rheumatoid arthritis,and may act as an important medium in the occurrence and development of rheumatoid arthritis.This paper explores the different roles of Ca^(2+)in the pathogenesis of rheumatoid arthritis from the perspective of Ca^(2+)and bone metabolism,calcium binding protein and Ca^(2+)homeostasis,and seeks for more new strategies for the diagnosis and treatment of rheumatoid arthritis,and the relationship between the two was confirmed by the related research of Chinese medicine on regulating Ca^(2+)to alleviate rheumatoid arthritis.

关 键 词：类风湿关节炎 CA^(2+) 骨代谢 钙结合蛋白 Ca^(2+)稳态 中药 

分 类 号：R593.22[医药卫生—内科学]