中西医治疗顽固性失眠的研究进展  

Research Progress on Treatment of Intractable Insomnia with Traditional Chinese and Western Medicine

作　　者：刘琼 关双 陈亚飞 王博 杜培艳 刘骏[1] 范吉平[1] 王忠[1] LIU Qiong;GUAN Shuang;CHEN Ya-fei;WANG Bo;DU Pei-yan;LIU Jun;FAN Ji-ping;WANG Zhong(Institute of Basic Research in Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Postdoctoral Research Station,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院博士后科研流动站,北京100700 [3]北京中医药大学中医学院,北京100029

出　　处：《中国中医基础医学杂志》2021年第10期1670-1674,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家科技重大专项课题“重大新药创制”(2017ZX09301-059)-基于模块药理学的临床价值方剂发现与评价技术。

摘　　要：顽性失眠多指病程超过2年以上的慢性失眠,临床容易反复且缠绵难愈。顽固性失眠的病因繁多,病理机制复杂且治疗不一。西医治疗顽固性失眠主要以苯二氮卓类药物为主,但长期服用后会产生药物依赖及撤药时反跳等反应,致大部分患者无法进行日常的工作与生活。近期有相关研究表明,失眠认知行为疗法是一种很有效的药物疗法。本文通过从治法、基础方等方面分析发现,中医治疗顽固性失眠结合中医辨证论治和整体观念的基本特点,从痰、瘀、虚等入手,首选方为血府逐瘀汤,常用药物首选酸枣仁和夜交藤,并得到现代药理学的验证。本文主要对近10年来治疗顽固性失眠的文献进行系统梳理总结和分析,以期为顽固性失眠的临床治疗提供思路与参考。Intractable insomnia usually refers to chronic insomnia with a course of more than 2 years,which is easy to be repeated in clinical and difficult to heal.There are many causes and complex pathological mechanisms and the treatment is different of the intractable insomnia.Western medicine treatment of intractable insomnia is mainly based on benzodiazepine drugs,but the reaction of drug dependence and anti-jump after long-term use,causing most patients unable to perform daily work and life.Recent researches have showed that cognitive behavioral therapy for insomnia is a very effective therapy.Through analysis of treatment,basic prescriptions,etc.,it is found that Chinese medicine treatment of intractable insomnia:combined with the basic characteristics of Chinese medicine-treatment based on syndrome differentiation and concept of organic wholeness,starting from phlegm,blood stasis and deficiency,the first selection prescription is Xuefu Zhuyu Decoction,and commonly used drugs preferred Suanzaoren(Ziziphi Spinosae Semen)and Yejiaoteng(Caulis Polygoni Multiflori)which have been verified by modern pharmacology.This article mainly summarizes and analyzes the literature on the treatment of intractable insomnia in the past 10 years,in order to provide ideas and references for the clinical treatment of intractable insomnia.

关 键 词：顽固性失眠 慢性失眠 中西医治疗 研究进展 

分 类 号：R338.63[医药卫生—人体生理学]