立体化学中构型标记和a/e键标识的探讨  

Discussion on Configuration Labeling and a/e Bond Marking in Stereochemistry

作　　者：顾从英 张梦晗 张大永 Gu Congying;Zhang Menghan;Zhang Dayong(School of Science China Pharmaceutical University,Nanjing 211198;School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学理学院,江苏南京211198 [2]中国药科大学基础医学与临床药学学院,江苏南京211198

出　　处：《广东化工》2021年第21期1-3,5,共4页Guangdong Chemical Industry

摘　　要：现有文献资料中有关立体化学的构型标记和环己烷a/e键标识的叙述不统一,难免造成概念模糊,不易系统掌握。该论文重新梳理了这些概念,对Newman式和标准Fischer投影式进行了详细释义,全面深入地探讨了有机立体化学中的构型标记,提出了赤/苏构型在标准Fischer投影式与Newman式之间快速互换书写方法,探索了环己烷中a/e键与两个亚甲基之间的空间位置关系规律及其在多环体系中的应用,同时还重新整理了D/L构型标记法和左右手快速标记R/S构型法,归纳了表示顺/反关系的Z/E、cis/trans、syn/anti构型标记的范围和运用区域。以资提供更加简捷明了和易于掌握的构型标记和环己烷a/e键标识方法。The descriptions of the stereochemical configuration labeling and the cyclohexane a/e bond marking method in the existing literature are inconsistent.It made the concept ambiguous and difficult to master systematically.In order to provide a more concise and easy-to-master configuration labeling method and cyclohexane a/e bond marking method,this article reorganized these concepts in the following aspects:1)Explained the Newman and the standard Fischer projection formula in detail;2)Discussed in-depth the conformational labelings in organic stereochemistry,and proposed the erythro/threo configuration with instant interchange writing methods between the standard Fischer projection and the Newman formula;3)Explored the spatial relationship between a/e bond with two methylene groups in cyclohexane and its application in polycyclic systems;4)Rearranged the D/L configuration labeling method and the rapid R/S configuration labeling method with left and right hand;5)Summarized the application of Z/E,cis/trans,and syn/anti configuration labeling.

关 键 词：构型 构象 Newman式 标准Fischer投影式 D/L 顺反异构 环己烷 a/e键 

分 类 号：G64[文化科学—高等教育学]