铑碳催化2,6-二甲基吡啶的氢化  

Rhodium on Carbon for Catalyzing Hydrogenation of 2,6-dimethylpyridine

作　　者：吴尖平 王丹燕 黄小东 施旭升 沈永淼 Wu Jianping;Wang Danyan;Huang Xiaodong;Shi Xusheng;Shen Yongmiao(Zhejiang Kente Catalytic Materials Co.,Ltd.,Taizhou 317300;School of Science,Zhejiang Sci-Tech University,Hangzhou 310018,China)

机构地区：[1]浙江肯特催化材料科技有限公司,浙江台州317300 [2]浙江理工大学理学院,浙江杭州310018

出　　处：《广东化工》2021年第21期41-43,共3页Guangdong Chemical Industry

基　　金：浙江省重点研发计划项目(2021C01080);浙江理工大学科研启动基金(18062144-Y)。

摘　　要：我们设计使用商用的5%铑碳催化剂对于二甲基吡啶的氢化进行了工艺优化,考察了催化剂种类及用量,温度,氢气压力,反应时间和反应溶剂对反应的影响。在2,6-二甲基吡啶的氢化反应中,研究了反应温度、氢气压力、催化剂用量、反应时间对反应的影响。经过调整得到在2,6-二甲基吡啶浓度为0.25 g/mL时,无水乙醇作为溶剂,Rh/C-Ⅴ催化剂用量为原料的6%(wt%),反应氢气压力为3.0 Mpa,反应温度为150℃,反应时间为2 h,此时原料转化率达到>99%,产率>99%,产物均为顺式产物,条件重现性及放大效果良好。A commercial 5% rhodium on carbon catalyst was designed for the hydrogenation of 2,6-dimethylpyridine.The effects of catalysts type and dosage,temperature,hydrogen pressure,reaction time and solvent on the reaction were investigated.In the hydrogenation of 2,6-dimethylpyridine,we analyze the influence of four factors including reaction temperature,hydrogen pressure,catalyst dosage and reaction time.After experiment,the optimal reaction conditions is that the conversion rate of raw material and the yield are both over 99%,when the concentration of 2,6-dimethylpyridine is 0.25 g/mL,anhydrous ethanol is used as solvent,the amount of Rh/C-V catalyst is 6% of raw material,the reaction hydrogen pressure is 3.0 Mpa,the temperature is 150℃ and the reaction time is 2 h.The products are all cis-2,6-dimethylpiperidine.

关 键 词：铑碳催化剂 催化氢化 2 6-二甲基吡啶 工艺优化 2 6-二甲基哌啶 

分 类 号：TQ016.8[化学工程]