1,2,3-三氮唑化合物的合成与表征  

Synthesis and Characterization of 1,2,3-azides

作　　者：肖颖 汪朝阳[1] 陈汉城 吴安理 杨如娥 罗时荷[1] Xiao Ying;Wang Zhaoyang;Chen Hancheng;Wu Anli;Yang Rue;Luo Shihe(School of Chemistry South China Normal University,Guangzhou 510006;Guangdong Andeli New Material Co.,Ltd.,Shantou 515824;Guangdong Dexing Polymer Film Materials Research Co.,Ltd.,Shantou 515824,China)

机构地区：[1]华南师范大学化学学院,广东广州510006 [2]广东安德力新材料有限公司,广东汕头515824 [3]广东德星聚合物薄膜材料研究有限公司,广东汕头515824

出　　处：《广东化工》2021年第19期3-4,共2页Guangdong Chemical Industry

基　　金：广东省科技计划项目(2020B121202008,2019B090905008);广东省自然科学基金(2021A1515012342)。

摘　　要：本文以烷基溴和叠氮化钠为原料,制备了有机叠氮化合物,进一步通过点击化学制备了一系列1,2,3-三氮唑小分子。通过^(1)H NMR、^(13)C NMR、IR等分析测试方法对6个产物进行了结构表征,证明合成的化合物为预期化合物,进一步探讨了三氮唑上不同的取代基结构对于反应的影响。特别是炔基药物分子炔孕酮的引入,有望为三氮唑及其衍生物在生物医药等领域的应用提供一定的实验基础。Alkyl bromide and sodium azide were used as raw materials to prepare organic azides,and a series of 1,2,3-triazole small molecules were prepared by click chemistry.The structures of the six products were characterized by ^(1)H NMR,^(13)C NMR and IR.the products were expected targets.Furthermore,the effect of different substituent structure on the reaction was discussed.Especially the introduction of drug molecule ethisterone,which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields.

关 键 词：点击化学 1 2 3-三氮唑 炔孕酮 烷基叠氮 

分 类 号：O61[理学—无机化学]