基于维生素D探讨补肾治疗桥本氏甲减的潜在分子机制  

To Explore the Potential Molecular Mechanism of Tonifying Kidney for Hashimoto’s Hypothyroidism Based on Vitamin D

作　　者：赵洁 周艳 高洁 柴艺汇 李文 秦忠 陈云志 ZHAO Jie;ZHOU Yan;GAO Jie;CHAI Yi-hui;LI Wen;QIN Zhong;CHEN Yun-zhi(Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou,550025,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《时珍国医国药》2021年第9期2225-2228,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81874376);贵州省科技计划项目(黔科合基础[2017]1401);贵州省教育厅项目(黔教合KY字[2017]041)。

摘　　要：维生素D作为一种新兴的内分泌免疫调节剂,对桥本氏甲减的发生发展发挥着多方面干预作用。桥本氏甲减是由桥本氏甲状腺炎发展到后期甲状腺受损所引起的以低代谢症候群为主要表现的一种甲减症状,属中医的"瘿病·虚劳"范畴,治疗宜从整体观念出发,以补肾为本,疏肝为标。前期课题组发现中医"肾精"概念与维生素D在多方面具有高度重叠性,并指出"维生素D可能是肾精的现代物质基础之一"。由此推测中医补肾治疗桥本氏甲减的分子机制与维生素D相关。As a new endocrine immunomodulator,vitamin D plays an important role in the occurrence and development of Hashimoto’s hypothyroidism.Hashimoto’s hypothyroidism belongs to the category of"goiter consumptive disease"in traditional Chinese Medicine.It is a hypothyroidism syndrome caused by the development of Hashimoto’s thyroiditis to the thyroid damage in the later stage,with hypo-metabolic syndrome as its major manifestation.The treatment of Hashimoto’s hypothyroidism should be performed with"kidney-tonifying"as the major approach and supplemented by"liver-soothing"in accordance with the principle of holism.In our previous research,it was found that the concept of"kidney essence"in traditional Chinese medicine was highly overlapping with vitamin D in many aspects,and pointed out that"vitamin D may be one of the modern material bases of kidney essence".Accordingly,our present study speculated and proposed that the molecular mechanism of traditional Chinese medicine therapy of kidney-tonifying might be correlated with vitamin D for the treatment of Hashimoto’s hypothyroidism.

关 键 词：维生素D 补肾 桥本氏甲减 分子机制 

分 类 号：R2-03[医药卫生—中医学]