Effects of piperacillin synthesis on the infterfacial tensions and droplet sizes  

作　　者：Yu Xie Guoming Huang Weiguo Hu Yujun Wang 

机构地区：[1]The State Key Laboratory of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China [2]North China Pharmaceutical Group Co.,Ltd.,Shijiazhuang 052165,China

出　　处：《Chinese Journal of Chemical Engineering》2021年第10期53-62,共10页中国化学工程学报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(2019YFA0905100);the National Natural Science Foundation of China(21878169 and 21991102);Tsinghua University Initiative Scientific Research Program(2018Z05JZY010)。

摘　　要：Piperacillin is a polar organic substance,and can reduce the interfacial tension of oil and water when dissolved in water.In this study,changes in dichloromethane–water interfacial tensions and microdroplet sizes during piperacillin synthesis from an aqueous solution of ampicillin and dichloromethane solution of 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride(EDPC)were observed using a pendent drop technique and a coaxial ring tube system with embedded high-speed camera,respectively.It was found that the rapid N-acylation reaction caused the piperacillin at the interface to synthesize rapidly and diffuse out slowly,resulting in the interfacial tension decreased from 19.5 m N·m-1 to 7.2 m N·m-1 rapidly and then increased slowly as the concentrations of ampicillin and EDPC were 0.05 mol·L-1 and 0.1 mol·L-1.Meanwhile,the increase in the concentration of EDPC increased the peak concentration of piperacillin at the interface,and the addition of ethyl acetate to the ampicillin solution promoted mass transfer and reduced the aggregation of piperacillin effectively.During synthesis,the interfacial tension decreased,leading to a change in droplet sizes in the micro-reaction system.The two-phase reaction was carried out in a coaxial ring tube,with ampicillin and EDPC solutions as continuous and dispersed phases,respectively.The reaction reduced the dripping flow area,and the addition of ethyl acetate to the ampicillin solution slightly affected the division of the flow pattern.Under the same flow conditions,the droplet sizes of the reaction group were smaller than those of the no reaction group.The experimental results demonstrated that the increase of the continuous phase,decrease in the dispersed phase flow rate,or increase in EDPC concentration making droplet sizes smaller,and the addition of ethyl acetate slightly affected droplet sizes.These findings are important for the design and optimization of piperacillin synthesis reactors.

关 键 词：Pendant drop Interfacial tension MICROCHANNEL Droplet size Piperacillin synthesis Mass transfer 

分 类 号：TQ460.1[化学工程—制药化工]