深吸气量及肺总量对慢性阻塞性肺疾病再次急性加重的预测价值  

Predictive value of inspiratory capacity and total lung capacity on acute exacerbation of chronic obstructive pulmonary disease

作　　者：陈敏[1] 王晓霞[1] 陈锋[1] CHEN Min;WANG Xiaoxia;CHEN Feng(Department of Pulmonary and Critical Care Medicine,the No.3 People’s Hospital of Chengdu,Chengdu,Sichuan 610031,P.R.China)

机构地区：[1]成都市第三人民医院呼吸与危重症医学科,四川成都610031

出　　处：《中国呼吸与危重监护杂志》2021年第10期690-693,共4页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的探讨深吸气量(IC)及肺总量(TLC)对慢性阻塞性肺疾病(简称慢阻肺)急性加重的预测价值。方法纳入2017年2月至2019年3月因急性加重住院的慢阻肺患者,收集其恢复期资料及出院后1年内的随访资料,并根据是否出现再次急性加重进行分组。结果共纳入372例患者,其中再次急性加重患者的年龄较大,TLC占预计值百分比(TLC%pred)较高,而IC占预计值百分比(IC%pred)及IC与TLC的比值(IC/TLC)较低。单变量回归分析显示,IC/TLC≤25%为慢阻肺急性加重患者病情缓解出院后近期再次急性加重的危险因素(P<0.001)。多变量回归分析显示,高龄(OR=1.25,95%CI 1.17~1.44,P<0.001)及IC/TLC≤25%(OR=1.68,95%CI 1.36~2.07,P<0.001)是再次急性加重的独立危险因素。结论IC/TLC下降是慢阻肺急性加重患者病情缓解后预后不良的独立危险因素。Objective To study the predictive value of inspiratory capacity(IC)and total lung capacity(TLC)on acute exacerbation of patients with chronic obstructive pulmonary disease(COPD).Methods The in-patients due to acute exacerbation of COPD(AECOPD)from February 2017 to March 2019 were recruited in the study.Research data were collected during the recovery period and one year follow-up,and the patients were divided into two groups according to whether there was another acute exacerbation.Results A total of 372 patients were included in the study.In the patients with acute exacerbation,the age and TLC as a percentage of the expected value(TLC%pred)were higher,while IC as a percentage of the expected value(IC%pred)and the ratio of IC and TLC(IC/TLC)were lower.Univariate analysis revealed that IC/TLC≤25%was a significant predictor of acute exacerbation(P<0.001)after the AECOPD patients were discharged.Multivariable analysis revealed age(OR=1.25,95%CI 1.17 to 1.44,P<0.001)and IC/TLC≤25%(OR=1.68,95%CI 1.36 to 2.07,P<0.001)were independent risk factors of AECOPD.Conclusions Decreased IC/TLC significantly correlates with poor prognosis of COPD.IC/TLC≤25%is an independent risk factor for acute exacerbation.

关 键 词：慢性阻塞性肺疾病 深吸气量 肺总量 

分 类 号：R563.9[医药卫生—呼吸系统]