产单核李斯特菌致新生儿败血症诊断学特征并文献复习  

Diagnostic features of neonatal sepsis caused by Listeria monocytogenes infection and literature review

作　　者：李慧[1] 张连红[2] 熊丽[2] 宋江勤 Li Hui;Zhang Lianhong;Xiong Li;Song Jiangqin(Department of Laboratory Medicine,The First People′s Hospital of Tianmen City,Tianmen 431700,China;Department of Neonatology,The First People′s Hospital of Tianmen City,Tianmen 431700,China)

机构地区：[1]天门市第一人民医院检验科,431700 [2]天门市第一人民医院新生儿科,431700

出　　处：《中华诊断学电子杂志》2021年第4期251-254,共4页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：湖北省卫生健康科研基金(WJ2019H208)。

摘　　要：目的探讨产单核李斯特菌感染致新生儿败血症的诊断学特征。方法回顾性分析2019年5月30日天门市第一人民医院新生儿科收治的1例产单核李斯特菌感染致新生儿败血症患儿的临床资料,并复习相关文献。结果患儿为胎龄32^(+6)周早产儿,生后呻吟、气促13 min,吸气三凹征;患儿外周血白细胞计数6.11×10^(9)/L,中性粒细胞绝对值4.2×10^(9)/L,单核细胞绝对值0.65×10^(9)/L,C反应蛋白16.78 mg/L;血气分析PH 7.22,动脉二氧化碳分压50 mmHg(1 mmHg=0.133 kPa),动脉氧分压67 mmHg,HCO_(3)^(-)20.5 mmol/L,碱剩余-7.3 mmol/L,动脉血氧饱和度89%;通过血培养最终诊断为产单核李斯特菌败血症,予以抗感染等对症治疗后,患儿体温正常,病原学指标复查均阴性,病情好转出院。结论及时发现、确诊及规范治疗是控制产单核李斯特菌感染新生儿病情及改善预后的关键。Objective To explore the diagnostic characteristics of neonatal sepsis caused by Listeria monocytogenes infection.MethodsThe clinical data of one case of neonatal sepsis caused by Listeria monocytogenes infection in Neonatology Department of The First People′s Hospital of Tianmen City on May 30,2019 was retrospectively analyzed,and the relevant literatures were reviewed.ResultsA premature infant with a gestational age of 32^(+6) weeks was first diagnosed with groaning and shortness of breath for 13 minutes after birth.The peripheral blood white blood cell count was 6.11×10^(9)/L,the absolute value of neutrophils was 4.2×10^(9)/L,the absolute value of monocytes was 0.65×10^(9)/L,and the C-reactive protein level was 16.78 mg/L.Blood gas analysis PH was 7.22,arterial partial pressure of carbon dioxide was 50 mmHg(1 mmHg=0.133 kPa),arterial partial pressure of oxygen was 67 mmHg,HCO_(3)^(-) was 20.5 mmol/L,alkali residue was-7.3 mmol/L,arterial oxygen saturation was 89%.The final diagnosis of Listeria monocytogenes sepsis was confirmed by blood culture.After anti-infection and other symptomatic treatment,the patient′s body temperature was normal and the reexamination result of the pathogenic indicators was negative.The case was cured and discharged.ConclusionTimely detection and diagnosis and standardized treatment are the keys to control the condition of newborns with Listeria monocytogenes infection and improve the prognosis.

关 键 词：婴儿 新生 产单核李斯特菌 败血症 

分 类 号：R72[医药卫生—儿科]