基于科学知识图谱的国际矮小症诊治研究热点及研究趋势分析  

Analysis of international research hotspots and trends in diagnosis and treatment of dwarfism based on scientific knowledge graph

作　　者：杨成会 崔芬 Yang Chenghui;Cui Fen(Editorial Department of Chinese Joural of Diagnostics (Electronic Edition), Jining Medical University, Jining 272013, China)

机构地区：[1]济宁医学院中华诊断学电子杂志编辑部,272013

出　　处：《中华诊断学电子杂志》2021年第4期273-277,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：济宁市重点研发计划项目(2020YXNS031)。

摘　　要：目的探讨国际矮小症诊断与治疗方面的研究热点及研究趋势。方法以“矮小症”为研究对象,采用CiteSpace科学知识图谱对2011至2020年Web of Science核心合集数据库中检索到的文献进行分析,以国家和机构发文量分析、关键词共现和突现分析、文献共被引聚类分析为主要研究方法,梳理10年来国际矮小症诊治研究领域国家和机构的发文情况、主要研究热点和研究趋势。结果共检索到9465篇矮小症相关文献,发文量前3位的国家分别为美国、德国和中国;发文量前3位的机构分别是哈佛大学、圣保罗大学和瑞典卡洛林斯卡医学院。对文献进行关键词突发性检测,主要为矮小症诊治相关指南、促性腺激素释放激素、矮小症预测及分类、脑垂体激素缺乏和自闭症。对文献进行共被引及聚类分析,共形成16个聚类,主要集中于矮小症的病因诊断分类,如生长激素缺乏症、特发性矮小症、软骨发育不全、青春期发育迟滞和几种较少见的遗传性疾病。根据高被引论文分析,研究主要集中在成人生长激素缺乏症、原发性胰岛素样生长因子1缺乏症和单纯性生长激素缺乏症。结论与矮小症相关的基因调控分析、诊断及疗效模型预测、社会心理功能评估为目前国际研究的热点及方向。Objective To explore the research hotspots and trends in diagnosis and treatment of dwarfism in the world.MethodsTaking"dwarfism"as the research object,CiteSpace scientific knowledge map was used to analyze literatures retrieved from the Web of Science core collection database from 2011 to 2020.The main research methods were analysis of national and institutional publications,keyword co-occurrence and emergency analysis and literature co-citation cluster analysis.The paper published by countries and institutions in the field of diagnosis and treatment of dwarfism,and the main research hotspots and trends in the past 10 years were summarized.ResultsA total of 9465 articles on dwarfism were retrieved,and the top three publication countries were the United States,Germany and China.The top three contributors were Harvard University,the University of Sao Paulo and Karolinska Institutet of Sweden.The literatures were tested for keywords of sudden onset,which mainly included guidelines for dwarfism,gonadotropin-releasing hormone,prediction and classification of dwarfism,pituitary hormone deficiency and autism.According to the co-citation analysis of the literatures,16 clusters were formed,which mainly focused on the etiological diagnostic classification of dwarfism,such as growth hormone deficiency,idiopathic short stature,achondroplasia,delayed puberty and several rare genetic diseases.According to the analysis of the highly cited papers,the studies focused on adult growth hormone deficiency,primary insulin-like growth factor 1 deficiency,and isolated growth hormone deficiency.ConclusionThe analysis of gene regulation,diagnosis,prediction of curative effect model and assessment of psychosocial function related to dwarfism are the focus and directions of international research at present.

关 键 词：矮小症 诊断 CITESPACE 文献计量学 研究热点 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]