芳酰基亚甲基丙二酸酯的无催化两步一锅法合成  

Catalyst-free Synthesis of Aroylmethylidene Malonates via Two-step in One Pot

作　　者：齐春 陈文龙 杨高升[1] QI Chun;CHEN Wen-long;YANG Gao-sheng(MOE Key Laboratory of Functionalized Molecular Solids, Anhui Key Laboratory of Molecule-based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China)

机构地区：[1]安徽师范大学化学与材料科学学院,功能性分子固体安徽省高校重点实验室,分子基材料安徽省重点实验室,安徽芜湖241002

出　　处：《合成化学》2021年第11期969-974,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金项目资助(21672005,21172002)。

摘　　要：芳酰基亚甲基丙二酸酯是一类重要的有机合成中间体。用二甲亚砜(DMSO)氧化α-溴代芳基乙酮生成的芳基乙酮醛,立即与丙二酸酯在无催化剂、4A分子筛为吸水剂、60℃条件下缩合,以两步一锅58%~85%的总产率合成了芳酰基亚甲基丙二酸酯。Aroylmethylidene malonate is an important intermediate in organic synthesis.Phenacyl bromides were oxidized with dimethyl sulfoxide(DMSO),and the resulting arylglyoxals were directly condensed with malonates at 60℃without catalyst,using 4A molecular sieve as water-absorbent.The total yields of aroylmethylidene malonates were 58%~85%in two steps.

关 键 词：芳酰基亚甲基丙二酸酯 合成 芳基乙酮醛 丙二酸酯 吸水剂 缩合 一锅法 

分 类 号：O622.5[理学—有机化学]