骨代谢过程中钙离子通道TRPV5、TRPV6的作用  

Role of TRPV5 and TRPV6 calcium channels in bone metabolism

作　　者：李超[1] 张贤[2] 邵家豪 Li Chao;Zhang Xian;Shao Jiahao(Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China;Affiliated Wuxi Hospital of Nanjing University of Chinese Medicine,Wuxi 214071,Jiangsu Province,China)

机构地区：[1]南京中医药大学,江苏省南京市210023 [2]南京中医药大学无锡附属医院,江苏省无锡市214071

出　　处：《中国组织工程研究》2022年第12期1950-1955,共6页Chinese Journal of Tissue Engineering Research

基　　金：无锡市卫生健康委员会科研重大项目(Z202020),项目负责人:张贤;南京中医药大学自然科学基金项目(XZR2020081),项目负责人:张贤。

摘　　要：背景:瞬态受体电位通道构成了一个庞大而多样的阳离子通道家族,作为细胞传感器对机体内外大量的物理和化学刺激做出反应。钙是骨组织的重要组成部分,钙相关调节因子可以通过Ca^(2+)浓度的改变在骨形成和骨吸收中发挥作用,而骨质疏松发生过程中的骨代谢较大程度上就是Ca^(2+)的代谢过程。TRPV5/TRPV6是跨细胞Ca^(2+)转运的重要通道,在瞬态受体电位家族中对于Ca^(2+)具有高度通透性,因此上皮Ca^(2+)通道与骨代谢之间存在着密切关系。目的:综述骨代谢与钙的关系、Ca^(2+)通道TRPV5/TRPV6的特性及生理功能和TRPV5/TRPV6与骨质疏松发生过程中骨代谢之间的关系,为祖国医学在抗骨质疏松中的具体机制研究提供更加充分的证据支持。方法:以"calcium channel,TRPV5,TRPV6,bone metabolism,osteoporosis,traditional Chinese medicine"为英文检索词,以"钙离子通道、TRPV5、TRPV6、骨代谢、中医药"为中文检索词,由第一作者检索2000年1月至2021年4月PubMed数据库、中国知网、万方全文数据库,查阅Ca^(2+)通道TRPV5/TRPV6与骨代谢研究相关的文献,最终保留58篇进行综述。结果与结论:(1)破骨细胞与成骨细胞的平衡在骨代谢活动维持正常状态中起重要作用,人体上皮组织中高度表达的Ca^(2+)通道TRPV5/TRPV6对全身Ca^(2+)代谢有着非常重要的作用。(2)Ca^(2+)通道TRPV5、TRPV6对Ca^(2+)具有高选择通透特性,在磷酸化、糖基化、泛素化等多种翻译修饰后对于骨代谢产生作用,进而对破骨细胞或者成骨细胞发挥效应,以抑制破骨细胞,增加钙的吸收,促进成骨作用。(3)中医药抗骨质疏松可能是通过增加体内肠道或者肾脏TRPV5/TRPV6的表达或TRPV5/TRPV6通道开放量增加,进一步提高TRPV5/TRPV6的活性,以达到抑制破骨细胞的骨吸收、促进成骨细胞的骨形成,最终发挥防治骨质疏松的作用。BACKGROUND:Transient receptor potential(TRP)channels constitute a large and diverse family of cationic channels,which act as cellular sensors to respond to a large number of physical and chemical stimuli in and out of the body.Calcium is an important part of bone tissue,and calcium-related regulatory factors can play a role in bone formation and resorption through changes in Ca2+concentration.The bone metabolism in the development of osteoporosis is to a large extent the metabolism process of calcium ions,and TRPV5/6 is an important channel of trans-cellular calcium ion transport.The TRP family is highly permeable to Ca2+,so there is a close relationship between epithelial calcium channels and bone metabolism.OBJECTIVE:To review the relationship between bone metabolism and calcium,the characteristics and physiological functions of Ca2+channels TRPV5/6,and the relationship between Ca2+channels TRPV5/6 and bone metabolism in the process of osteoporosis,which will provide more sufficient evidence for the research on the specific mechanism of anti-osteoporosis in Chinese medicine.METHODS:The first author searched PubMed,CNKI,and WanFang databases for the literatures related to calcium channel TRPV5/6 and bone metabolism published from January 2000 to April 2021 using the keywords of"calcium channel,TRPV5,TRPV6,bone metabolism,traditional Chinese medicine"in English and Chinese,respectively.Finally,58 articles were retained for review.RESULTS AND CONCLUSION:(1)The balance of osteoclasts and osteoblasts plays an important role in normal bone metabolism.The highly expressed calcium channels TRPV5/6 in human epithelial tissue play a very important role in calcium metabolism throughout the body.(2)The Ca2+channels TRPV5/6 were highly selective and permeable to Ca2+,and played an effect on bone metabolism after phosphorylation,glycosylation,ubiquitination and other translational modifications.They then exert an effect on osteoclasts or osteoblasts,thereby inhibiting osteoclasts,increasing calcium absorption,and promoting o

关 键 词：TRP离子通道 骨代谢 骨质疏松 TRPV5 TRPV6 作用进展 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]