颅骨修补材料三维数字化塑形聚醚醚酮、钛网临床应用优势的比较  

Comparison of clinical application of skull repair materials of three-dimensional digital shaping polyether ether ketone and titanium mesh

作　　者：王一明 杨凤东[1] 毛文斌 贾鑫 卫书欣 魏新亭[1] Wang Yiming;Yang Fengdong;Mao Wenbin;Jia Xin;Wei Shuxin;Wei Xinting(First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第一附属医院,河南省郑州市450052

出　　处：《中国组织工程研究》2022年第34期5492-5497,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:越来越多新兴的修补材料用于颅骨缺损的修补,何种修补材料是最佳选择尚无明确定论。目的:初步探讨三维数字化塑形聚醚醚酮、钛网两种颅骨修补材料在颅骨修补中的应用性比较。方法:回顾性分析2017年1月至2020年9月在郑州大学第一附属医院神经外科接受颅骨修补174例患者的临床资料,男126例,女48例,平均年龄(43.9±12.0)岁,其中选择聚醚醚酮修补材料者95例,选择钛网修补材料者79例。获取术中资料、术后并发症及随访结果情况(包括癫痫发作、需手术处理的血肿、感染、皮下积液、脑脊液漏、修补材料松动或凹陷、植入物外露等及主观感受),比较两组是否存在差异。试验方案符合郑州大学第一附属医院伦理委员会要求。结果与结论:(1)174例患者术后随访时间为2-37个月,平均(17.2±12.4)个月;(2)聚醚醚酮组与钛网组的术后总并发症发生率分别为20%,26%,组间比较差异无显著性意义(P>0.05);(3)术后随访过程中,两组患者癫痫、血肿发生、手术部位感染、皮下积液、脑脊液漏、修补材料松动或凹陷发生情况比较差异无显著性意义(P>0.05),头部双侧对称性比例比较差异无显著性意义(P>0.05),聚醚醚酮组患者的修补材料外露、震动感和冷热感体验发生比例低于钛网组(P<0.05);(4)结果表明,两组修补材料均具有良好的生物亲和性,聚醚醚酮修补材料术后发生的材料外露、震动感和冷热感觉体验要少于钛网修复材料。BACKGROUND:More and more emerging repair materials are used for the repair of skull defects,and it is not clear which repair material is the best choice.OBJECTIVE:To preliminarily compare the application of three-dimensional digital shaping polyether ether ketone and titanium mesh in skull repair.METHODS:The clinical data of 174 patients who underwent skull repair in the Department of Neurosurgery of First Affiliated Hospital of Zhengzhou University from January 2017 to September 2020 were analyzed retrospectively.There were 126 males and 48 females with an average age of(43.9±12.0)years.Among them,95 cases were treated with polyether ether ketone repair materials and 79 cases with titanium mesh.The intraoperative data,postoperative complications and follow-up results(including seizures,hematoma which requiring surgical treatment,infection,subcutaneous effusion,cerebrospinal fluid leakage,loosening or depression of repair materials,exposure of implants,and subjective feelings)were obtained.The differences between the two groups were compared.The protocol was in accordance with the requirements of the Ethics Committee of First Affiliated Hospital of Zhengzhou University.RESULTS AND CONCLUSION:(1)The postoperative follow-up time was from 2 to 37 months,and the average follow-up time was(17.2±12.4)months in 174 patients.(2)The total incidence of postoperative complications in the polyether ether ketone group and the titanium mesh group was 20%and 26%,respectively,and there was no significant difference between the two groups(P>0.05).(3)There was no significant difference in epilepsy,hematoma,surgical site infection,subcutaneous effusion,cerebrospinal fluid leakage,loosening or depression of repair materials between the two groups(P>0.05).There was no significant difference in proportion of bilateral symmetry of head between the two groups(P>0.05).Occurrence ratios of exposure of repair materials,vibration sensation,hot and cold experience were lower in the polyether ether ketone group than those in the titanium me

关 键 词：颅骨修补 聚醚醚酮 钛网 修补材料 术后并发症 修补材料外露 局部感觉异常 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]