锰元素在生物材料中的应用:现状和问题  

Application of manganese in biomaterials: current situation and problems

作　　者：张畅 喻正文 Zhang Chang;Yu Zhengwen(School of Stomatology,Zunyi Medical University,Zunyi 563099,Guizhou Province,China;Key Laboratory of Oral Disease Research,Guizhou Institution of Higher Education,Zunyi 563099,Guizhou Province,China)

机构地区：[1]遵义医科大学口腔医学院,贵州省遵义市563099 [2]贵州省普通高等学校口腔疾病研究特色重点实验室,贵州省遵义市563099

出　　处：《中国组织工程研究》2022年第34期5504-5511,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家重点研发计划项目(2016YFC1102800),项目参与人:喻正文;贵州省医用生物材料研发人才基地(黔人领发[2018]3号),项目参与人:喻正文;遵义市科学技术局、遵义医科大学附属口腔医院联合科技研发资金项目(遵市科合社字(2018)240号),项目参与人:喻正文;遵义医科大学学术新苗培养及创新探索专项项目(黔科合平台人才[2017]5733-057),项目参与人:喻正文。

摘　　要：背景:金属元素在人体中扮演了重要的角色。近年来,金属元素在生物材料中的应用令人瞩目,其功能与效用正在被快速地挖掘与拓宽。相比于镁、锌等近些年研究得比较多的金属元素,锰元素是生物材料学研究领域中的后起之秀。目的:总结和归纳锰元素在生物材料中的应用现状和存在的问题。方法:由第一作者通过计算机检索中国知网、万方数据、爱思唯尔ScienceDirect数据库及PubMed数据库,检索2010年2月至2021年2月所有相关文章。中文检索词为"锰、生物材料、生物医用金属材料、陶瓷生物材料、纳米材料、生物高分子材料、骨组织工程、药物递送、肿瘤治疗",英文检索词为"Manganese,Biomaterials,alloy,degradable metals,corrosion,biomedical metallic materials,Ceramic biomaterial,Nanomaterial,biopolymer material,Bone tissue engineering,Drug delivery,Cancer therapy",最终纳入72篇文献进行归纳总结。结果与结论:(1)目前的研究证据提示,将锰元素引入生物材料中可显著改善生物材料的力学性能和耐腐蚀降解性能,并有效提高生物材料的生物相容性、促成骨和抗菌等性能,表明将锰离子作为功能性离子掺入生物材料中有着良好的应用价值。(2)现阶段关于锰离子在生物材料中的研究还处在基础实验阶段,已有研究表明将锰离子结合到胶原-羟基磷灰石支架上会促进骨髓间充质干细胞体外成骨和小鼠颅骨缺损部位的新骨再生,进一步增强了骨诱导能力。(3)锰元素的优良特性使其在医用金属材料、骨组织工程材料、药物递送及肿瘤治疗方面有着广阔的应用前景,未来有望为锰元素相关生物材料的基础和临床应用提供新的方向。BACKGROUND:Metal elements play an important role in the human body.In recent years,the application of metal elements in biomaterials has attracted attention,and its functions and effects are being rapidly explored and broadened.Compared with the metal elements that have been studied more in recent years,such as magnesium and zinc,manganese is a rising star in the field of biomaterials research.OBJECTIVE:To summarize and review application status and existing problems of manganese in biomaterials.METHODS:The first author searched CNKI,Wanfang,ScienceDirect,and PubMed databases by computer to retrieve all relevant articles published from February 2010 to February 2021.The Chinese search terms were"manganese,biomaterials,biomedical metallic materials,ceramic biomaterial,nanomaterial,biopolymer material,bone tissue engineering,drug delivery,cancer therapy",and the English search terms were"manganese,biomaterials,alloy,degradable metals,corrosion,biomedical metallic materials,ceramic biomaterial,nanomaterial,biopolymer material,bone tissue engineering,drug delivery,cancer therapy".Finally,72 included articles were summarized.RESULTS AND CONCLUSION:(1)The current research found that the introduction of manganese into biomaterials can significantly improve the mechanical properties and corrosion resistance of biomaterials,and effectively improve the biocompatibility,bone formation and antibacterial properties of biomaterials,indicating that the incorporation of manganese ions as functional ions into biological materials has good research value.(2)The current research on manganese ions in biomaterials mainly focuses on in vivo and in vitro experiments.The existing studies have shown that combining manganese ions with collagenhydroxyapatite scaffolds can promote osteogenesis of bone marrow mesenchyme stem cells in vitro and regeneration of new bone in mouse skull defects,and further enhance the osteoinductivity.(3)In view of the excellent properties of manganese,it can have broad application prospects in medical metal mat

关 键 词：锰 生物材料 生物医用金属材料 陶瓷生物材料 纳米材料 生物高分子材料 骨组织工程 药物递送 肿瘤治疗 综述 

分 类 号：R453[医药卫生—治疗学] R363[医药卫生—临床医学]