肥胖2型糖尿病患者半乳糖凝集素-3与胰岛素抵抗的相关性分析  

作　　者：励晶[1] 夏东霞[1] 陈奋[1] 

机构地区：[1]宁波大学医学院附属医院,315020

出　　处：《浙江临床医学》2021年第11期1633-1635,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划项目(2019KY192)。

摘　　要：目的探讨半乳糖凝集素-3(Gal-3)水平在2型糖尿病(T_(2)DM)肥胖和非肥胖人群中的分布差异及影响因素。方法检测健康体检者(70例)、非肥胖初发T_(2)DM患者(75例)和肥胖初发T_(2)DM患者(72例)血清中Gal-3及胰岛素水平、肝功能、血脂、空腹血糖及糖化血红蛋白、c-反应蛋白,分析三组人群Gal-3、HOMA-IR及HbAlC水平、C反应蛋白的差异,并采用多元回归模型分析Gal-3的影响因素结果肥胖和非肥胖T_(2)DM组中Gal-3、HOMA-IR、FBG、HbA1C、血脂指标、血尿酸均高于正常组(P<0.05);而肥胖T_(2)DM组Gal-3、BMI、HOMA-IR、肝功能指标、血脂指标及血尿酸高于非肥胖T_(2)DM组(P<0.05)。非肥胖T_(2)DM与肥胖T_(2)DM组间FBG和HbAlC差异无统计学意义(P>0.05)。多元回归分析显示,在T_(2)DM患者中HOMA-IR、BMI与Gal-3水平呈正相关。结论在2型糖尿病人群中,胰岛素抵抗、BMI与Gal-3密切相关。抑制Gal-3水平可能是治疗胰岛素抵抗和犯胖2型糖尿病的新途径。Objective To investigate the distribution of serum Gal-3 levels in obese and non-obese TDM patients,and to observe the influencing factors of Gal-3 levels in T_(2)DM patients.Methods The serum levels of Gal-3,insulin,liver function,blood lipid,fasting blood glucose,glycosylated hemoglobin and C-reactive protein were detected in 70 normal subjects,75 non-obese patients with newly diagnosed T_(2)DM and 72 obese patients with newly diagnosed T_(2)DM.The differences of Gal-3,HOMA-IR,HbAlc and C-reactive protein among the three groups were analyzed,and the influencing factors of Gal-3 were analyzed by multiple regression model.Results The levels of Gal-3,HOMA-IR,FBG,HbAlc,blood lipid and uric acid in obese and non-obese T_(2)DM groups were significantly higher than those in normal group(P<0.05).The levels of Gal-3,BMI,HOMA-IR,liver function,blood lipid and uric acid in obese T_(2)DM group were higher than those in non-obese T_(2)DM group(P<0.05).There was no significant difference in FBG and HbAlc between non-obese T_(2)DM and obese T_(2)DM groups(P>0.05).Multiple regression analysis showed that HOMA-IR and BMI were significantly positive correlated in patients with type 2 diabetes.Conclusion Insulin resistance and BMI are closely related to Gal-3 in patients with type 2 diabetes mellitus.Inhibition of Gal-3 level may be a new way to treat insulin resistance and obese type 2 diabetes.

关 键 词：2型糖尿病 肥胖 GALECTIN-3 胰岛素抵抗 

分 类 号：R54[医药卫生—心血管疾病]