左氧氟沙星的单晶制备及其结构表征  

Single crystal culture and structure characterization of levofloxacin

作　　者：赖群萍[1] 高浩凌 李昌芳 朱琳 吴利鑫 陈广军 曹瑞伟 LAI Qun-ping;GAO Hao-ling;LI Chang-fang;ZHU Lin;WU Li-xin;CHEN Guang-jun;CAO Rui-wei(Research&Development Center,Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China;Changhai Biological Company,Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China;Zhejiang Changhai Pharmaceutical Co.,Ltd.,Shaoxing 312300,China)

机构地区：[1]浙江医药股份有限公司研究院,浙江绍兴312300 [2]浙江医药股份有限公司昌海生物分公司,浙江绍兴312300 [3]浙江昌海制药有限公司,浙江绍兴312300

出　　处：《现代药物与临床》2021年第10期2032-2038,共7页Drugs & Clinic

摘　　要：目的培养左氧氟沙星单晶,进行结构表征。方法用乙腈–水体系培养单晶,并用单晶X射线衍射仪(SXRD)检测分析。结果制备得到左氧氟沙星无色片状晶体,该晶胞属于单斜晶系,空间群为P21,分子式为C_(18)H_(2)0FN_(3)O_(4)·H_(2)O,相对分子质量为379.38,晶体密度为1.469 mg/mm^(3),绝对构型为S构型。结论实验证明了左氧氟沙星的立体构型,培养的晶体晶型为一水合物。Objective To cultivate single crystal of levofloxacin,and to characterize the structure of Levofloxacin.Methods Cultivate single crystals with acetonitrile-water system,and single crystal X-ray diffractometer (SXRD) was used to detect and analyze.Results Levofloxacin colorless acicular crystal was obtained,and SXRD confirmed the monoclinic lattice with space group P21 in levofloxacin.The chemical formula and relative molecular mass were C_(18)H_(2)0FN_(3)O_(4)·H_(2)O and 379.38,and crystal density was 1.469 mg/mm^(3),absolute configuration was S style.Conclusion crystal structure of levofloxacin is characterized,and the crystal form of the cultured crystal is levofloxacin monohydrate.

关 键 词：左氧氟沙星 单晶X射线衍射 结构表征 

分 类 号：R912[医药卫生—药学]