益心汤治疗慢性肺源性心脏病的疗效观察  

Clinical observation of Yixin tang in patients with chronic pulmonary heart disease

作　　者：王菲 韩天雄[1] 施红[1] 王磊 Wang Fei;Han Tianxiong;Shi Hong;Wang Lei(Department of Integrated Traditional Chinese and Western Medicine,Shanghai Tenth People′s Hospital,Shanghai 200072,China;Shanghai Qunli Traditional Chinese Medicine Outpatient Department,Shanghai 200000,China)

机构地区：[1]上海市第十人民医院中西医整合医学科,200072 [2]上海市群力中医门诊部,200000

出　　处：《中国医师进修杂志》2021年第11期1015-1019,共5页Chinese Journal of Postgraduates of Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划(2018—2020年)建设项目(ZY(2018-2020)-CCCX-1003,ZY-(2018-2020)-ZYBZ23)。

摘　　要：目的探讨益心汤治疗慢性肺源性心脏病(CPHD)的临床疗效。方法回顾性分析2018年4月至2020年4月上海市第十人民医院72例CPHD患者的临床资料。其中,采用常规西医治疗36例(对照组),采用常规西医联合益心汤治疗36例(观察组)。比较两组治疗前后左心室射血分数(LVEF)、第1秒用力呼气容积与用力肺活量比值(FEV_(1)/FVC)、D-二聚体(D-D)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、圣乔治呼吸问卷(SGRQ)评分和中医症候评分。结果两组治疗前各项指标比较差异无统计学意义(P>0.05)。观察组治疗后FEV_(1)/FVC和LVEF明显高于对照组[(89.01±3.24)%比(78.13±3.52)%和(60.32±2.36)%比(52.80±3.23)%],TNF-α、IL-6、D-D、中医症候评分及SGRQ总分、活动受限评分、症状评分、疾病影响评分明显低于对照组[(6.95±2.67)pg/L比(10.45±4.07)pg/L、(4.36±1.24)pg/L比(6.90±7.42)pg/L、(0.32±0.13)pg/L比(1.07±0.43)pg/L、(14.50±3.00)分比(16.43±3.08)分、(20±12)分比(50±20)分、(21±15)分比(45±14)分、(22±11)分比(65±16)分和(17±10)分比(47±14)分],差异有统计学意义(P<0.05)。结论在常规西医治疗的基础上加用益心汤治疗CPHD,能有效改善心肺功能和炎性反应状态,提高生命质量。Objective To investigate the clinical efficacy of Yixin tang in patients with chronic pulmonary heart disease(CPHD).Methods The clinical data of 72 patients with CPHD in Shanghai Tenth People′s Hospital from April 2018 to April 2020 were retrospectively analyzed.Among them,36 patients were treated with conventional western medicine therapy(control group),and 36 patients were treated with Conventional western medicine therapy and Yixin tang(observation group).The left ventricular ejection fraction(LVEF),forced expired volume in one second to forced vital capacity ratio(FEV_(1)/FVC),D-dimer(D-D),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),St.George respiratory questionnaire(SGRQ)score and Chinese medicine syndrome score before and after treatment were compared between 2 groups.Results There were no statistical differences in the indexes before treatment between 2 groups(P>0.05).The FEV1/FVC and LVEF after treatment in observation group were significantly higher than those in control group:(89.01±3.24)%vs.(78.13±3.52)%and(60.32±2.36)%vs.(52.80±3.23)%,the TNF-α,IL-6,D-D,Chinese medicine syndrome score and SGRQ total score,limitation of activity score,symptom score,disease impact score were significantly lower than those in control group:(6.95±2.67)pg/L vs.(10.45±4.07)pg/L,(4.36±1.24)pg/L vs.(6.90±7.42)pg/L,(0.32±0.13)pg/L vs.(1.07±0.43)pg/L,(14.50±3.00)scores vs.(16.43±3.08)scores,(20±12)scores vs.(50±20)scores,(21±15)scores vs.(45±14)scores,(22±11)scores vs.(65±16)scores and(17±10)scores vs.(47±14)scores,and there were statistical differences(P<0.05).Conclusions The conventional western medicine treatment combined with Yixin tang can effectively improve cardiopulmonary function,inflammatory reaction and quality of life.

关 键 词：肺心病 治疗结果 益心汤 

分 类 号：R259[医药卫生—中西医结合]