银杏叶滴丸联合瑞舒伐他汀对老年冠心病患者的临床效果  

Clinical Effect of Ginkgo Biloba Dropping Pills Combined with Rosuvastatin on Elderly Patients with Coronary Heart Disease

作　　者：杨翠玲 张龙 叶莎[1] 张丽娥[1] 黄丽丽[3] YANG Cui-ling;ZHANG Long;YE Sha;ZHANG Li-e;HUANG Li-li(Department of Geriatric Cardiology,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China;Department of Cardiology,Xi'an Daxing Hospital,Xi'an,Shaanxi,710016,China;Ultrasound Research Laboratory,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China)

机构地区：[1]西安交通大学第二附属医院老年心血管科,陕西西安710004 [2]西安大兴医院心血管内科,陕西西安710016 [3]西安交通大学第二附属医院超声研究室,陕西西安710004

出　　处：《现代生物医学进展》2021年第18期3490-3493,3447,共5页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2020SF-254)。

摘　　要：目的:研究银杏叶滴丸联合瑞舒伐他汀对老年冠心病患者的临床效果。方法:选择2017年8月~2019年12月于我院的75例老年冠心病患者,将其随机分为两组。对照组口服瑞舒伐他汀,观察组联合口服银杏叶滴丸联合瑞舒伐他汀。比较两组的左室舒张末径(Left ventricular end diastolic diameter, LVEDD)、心输出量(Cardiac output, CO)和左室射血分数(Left ventricular ejection fraction, LVEF);血清白细胞介素-2 (Interleukin-2, IL-2)、P选择素、肿瘤坏死因子-α(Tumor necrosis factor-α, TNF-α)水平。结果:观察组的有效率95.49%,明显高于对照组71.05%(P<0.05);治疗后,两组的纤维蛋白原、全血高切黏度、红细胞聚集指数、全血低切黏度、最大血小板聚集率和血浆黏度、LVEDD、血清IL-2、P选择素、TNF-α水平明显降低(P<0.05),且观察组明显低于对照组,CO以及LVEF明显升高(P<0.05),且观察组上述指标的变化均优于对照组(P<0.05)。结论:银杏叶滴丸联合瑞舒伐他汀能有效抑制老年冠心病患者体内的炎性反应程度,改善血液流变学,恢复患者的心功能,值得推广。Objective:To investigate the effect of Ginkgo biloba dropping pills combined with rosuvastatin on elderly patients with coronary heart disease.Methods:Selected 75 cases of elderly patients coronary heart disease with coronary heart disease who were treated in our hospital from August 2017 to December 2019,divided into two groups randomly.The control group was treated with rosuvastatin,and the observation group was treated with ginkgo leaf drop pills combined with rosuvastatin.LVEDd,CO,LVEF,serum levels of IL-2,P-selectin and TNF-αwere compared between the two groups.Results:The effective rate of the observation group was 95.49%,which was significantly higher than 71.05%of the control group(P<0.05).After treatment,the two groups had significant levels of fibrinogen,whole blood high shear viscosity,red blood cell aggregation index,whole blood low shear viscosity,maximum platelet aggregation rate,plasma viscosity,LVEDD,serum IL-2,P-selectin,and TNF-αlevels Decrease(P<0.05),and the observation group was significantly lower than the control group,CO and LVEF were significantly increased(P<0.05),and the changes in the above indicators of the observation group were better than those of the control group(P<0.05).Conclusion:Ginkgo biloba dripping pills combined with rosuvastatin can effectively inhibit the inflammatory reaction in elderly patients with coronary heart disease,improve hemorheology,and restore the heart function of patients.

关 键 词：银杏叶滴丸 瑞舒伐他汀 老年冠心病 血液流变学 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]