白细胞、C反应蛋白与凝血指标在哮喘发作期患儿的临床意义  

Clinical significance of White Blood Cell,C-reactive Protein and Coagulation Indicators in Children with Asthma Exacerbation

作　　者：周立娜[1] 朱旭明 张健[3] 陈茜 崔玉宝 ZHOU Li-na;ZHU Xu-ming;ZHANG Jian;CHEN Xi;CUI Yu-bao(Department of Respiratory,Wuxi Children's Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu,214023,China;Department of Clinical Laboratory,Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi,Jiangsu,214023,China;Department of Clinical Laboratory,Wuxi Children's Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu,214023,China)

机构地区：[1]南京医科大学附属无锡儿童医院呼吸科,江苏无锡214023 [2]南京医科大学附属无锡人民医院检验科,江苏无锡214023 [3]南京医科大学附属无锡儿童医院检验科,江苏无锡214023

出　　处：《现代生物医学进展》2021年第19期3738-3742,共5页Progress in Modern Biomedicine

基　　金：江苏省重点研发计划项目(BE2018627)。

摘　　要：目的:探讨白细胞(WBC)、C反应蛋白(CRP)与常见凝血指标凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、抗凝血酶Ⅲ(ATⅢ)、D二聚体(D-D)在哮喘发作期儿童的临床意义。方法:选取发作期哮喘儿童,根据发作严重程度分为轻度、中度、重度3组。比较指标的组间差异,Pearson相关计算WBC、CRP与凝血指标的相关性,Logistic评估中度或重度哮喘发作期的影响因素。结果:全血WBC在中度组(12.02×10^(9)/L±4.61×10^(9)/L)显著高于轻度组(9.56×10^(9)/L±3.21×10^(9)/L,P<0.05),重度组(12.91×10^(9)/L±3.14×10^(9)/L)显著高于轻度组(9.56×10^(9)/L±3.21×10^(9)/L,P<0.05);重度组抗凝血酶ATⅢ(10^(9)%±13%)高于轻度组(99%±13%,P<0.05)。WBC与FIB正相关(r=0.297,P=0.018),CRP与TT(r=-0.330,P=0.008)、ATⅢ(r=-0.375,P=0.002)负相关,与FIB(r=0.496,P=0.001)、D-D(r=0.326,P=0.009)正相关。Logistic回归显示校正性别年龄的WBC影响重度组的比值比(OR)为1.602。结论:WBC和儿童哮喘发作严重程度有关,哮喘发作期儿童体内炎症状态与凝血指标存在一定关联。Objective:To discuss clinical significance of white blood cell(WBC),c-reactive protein(CRP)and common coagulation indicators including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),antithrombinⅢ(ATⅢ),D-dimer(D-D)in children with asthma exacerbation.Methods:Children with asthma exacerbation were enrolled and divided into mild,moderate and severe exacerbation groups.Levels of indicators were compared among groups.Pearson correlation analysis was performed to assess correlations between WBC,CRP and coagulation indicators.Logistic regression analysis was carried out to evaluate influence factors on moderate and severe asthma exacerbation.Results:WBC level was higher in moderate group(12.02×10^(9)/L±4.61×10^(9)/L)compared with mild group(9.56×10^(9)/L±3.21×10^(9)/L,P<0.05),and was also higher in severe group(12.91×10^(9)/L±3.14×10^(9)/L)compared with mild group(9.56×10^(9)/L±3.21×10^(9)/L,P<0.05).ATⅢlevel was higher in severe group(10^(9)%±13%)compared with mild group(99%±13%,P<0.05).WBC was positively correlated with FIB(r=0.297,P=0.018).CRP was negatively correlated with TT(r=-0.330,P=0.008),ATⅢ(r=-0.375,P=0.002),and positively correlated with FIB(r=0.496,P=0.001),D-D(r=0.326,P=0.009).Logistic regression analysis showed odd ratio of WBC to exert effect on severe group was1.602.Conclusions:WBC can exert effect on severity of asthma exacerbation in children.There are some relationships between inflammatory stage and coagulation indicators in children with asthma exacerbation.

关 键 词：白细胞 C反应蛋白 凝血 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]