便携式静电纺丝装置在医学方面的应用  

Application of Portable Electrospinning Devices in Medicine

作　　者：刘钟 刘现峰 王学艳 张俊 于淼 相宏飞[3] 陈勇 龙云泽[1,5] LIU Zhong;LIU Xianfeng;WANG Xueyan;ZHANG Jun;YU Miao;XIANG Hongfei;CHEN Yong;LONG Yunze(College of Physics,Qingdao University,Qingdao 266071,China;Qingdao Junada Technology Co.Ltd,Qingdao 266199,China;Department of Orthopedics,The Affiliated Hospital of Qingdao University,Qingdao 266035,China;Qingdao Yuren Medical Technology Co.Ltd,Qingdao 266111,China;State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学物理科学学院,山东青岛266071 [2]聚纳达(青岛)科技有限公司,山东青岛266199 [3]青岛大学附属医院骨科,山东青岛266035 [4]青岛钰仁医疗科技有限公司,山东青岛266111 [5]青岛大学生物多糖纤维成形与生态纺织国家重点实验室,山东青岛266071

出　　处：《青岛大学学报（工程技术版）》2021年第4期40-54,61,共16页Journal of Qingdao University(Engineering & Technology Edition)

基　　金：国家重点研发计划(2019YFC0121402,2019YFC0121404,2019YFC0121405);国家自然科学基金(51973100,11904193);生物多糖纤维成形与生态纺织国家重点实验室(RZ2000003334);青岛市博士后应用研究项目(2020年)。

摘　　要：针对传统纳米纤维制备装置存在的运输困难、需要外部电源和灵活性差的现状,为解决在医学伤口敷料方面应用受限的问题,本文综述了不依赖外部电源的小型便携式静电纺丝装置组成和应用。通过对电纺纳米纤维的形态结构、聚合物组成、抗菌性能、止血效果、促进组织修复能力进行讨论,提出原位电纺的概念,即根据患者情况在伤口上直接快速制备纳米纤维敷料膜,用于肝脏止血、烧烫伤处理、脑膜封闭等。最后,讨论了便携式静电纺丝装置在个性化美容和伤口敷料等方面的研究挑战和发展趋势。本综述为便携式静电纺丝装置的原位应用提供参考。For the current situation of difficult transportation,external power supply,and poor flexibility in traditional nanofiber preparation devices,in order to solve the problem of limited application in medical wound dressings,this paper summarizes the composition and medical application of small portable electrospinning devices independent of external power supply.By discussing the morphological structure,polymer compositions,antibacterial properties,hemostatic effect,and promoting tissue repair ability of electrospun nanofibers,the concept of in-situ electrospinning is proposed,that is,the nanofibers dressings films are directly and quickly prepared on the wound according to the patient′s situation,especially in hemostasis of liver,burn and scald treatment,meningeal sealing,etc.Finally,the research challenge and development trend of portable electrospinning devices in individual cosmetic and wound dressings are considered for further study.This review provides a reference for the in-situ application of portable electrospinning devices in medicine.

关 键 词：静电纺丝 聚合物纳米纤维 仪器 医学 

分 类 号：TQ340.64[化学工程—化纤工业] R318.08[医药卫生—生物医学工程]