亲环素A和白细胞分化抗原147与动脉粥样硬化及缺血性心脑血管病的研究进展  

Research progress of cyclophilin A and cluster of differentiation 147 in atherosclerosis and ischemic cardio-cerebrovascular diseases

作　　者：刘璐 张文彦 李世英 Liu Lu;Zhang Wenyan;Li Shiying(Neurology,Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院神经内科,唐山063000

出　　处：《心脑血管病防治》2021年第5期488-491,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：河北省医学科学研究课题计划(20201243)。

摘　　要：动脉粥样硬化(AS)作为一种慢性炎症性病理过程,是缺血性心脑血管病(ICCVD)发生、发展的重要病理学基础。研究显示,亲环素A(CyPA)及其细胞表面受体白细胞分化抗原147(CD147)参与AS及ICCVD的发生、发展。本文主要综述了CyPA和CD147在AS中的作用以及对ICCVD的影响,以期为临床诊疗提供参考。Atherosclerosis(AS),a chronic inflammatory process,is an important pathological basis for the occurrence and development of ischemic cardio-cerebrovascular disease(ICCVD).Studies have shown that cyclophilin A(CyPA)and its cell surface receptor,cluster of differentiation 147(CD147),are involved in the occurrence and development of AS and ICCVD.In this paper,the mechanism of CyPA and CD147 in AS and their influence on ICCVD were reviewed,so as to provide reference for clinical diagnosis and treatment.

关 键 词：亲环素A 白细胞分化抗原147 动脉粥样硬化 缺血性心脑血管病 

分 类 号：R543.5[医药卫生—心血管疾病] R743[医药卫生—内科学]